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Ultra-short celiac disease exhibits differential genetic and immunophenotypic features compared to conventional celiac disease.
Mata-Romero, Pilar; Martín-Holgado, Daniel; Ferreira-Nossa, Hal C; González-Cordero, Pedro L; Izquierdo-Martín, Ana; Barros-García, Patricia; Fernandez-Gonzalez, Nuria; Fernández-Pereira, Luis; Cámara-Hijón, Carmen; Molina-Infante, Javier.
Afiliación
  • Mata-Romero P; Department of Gastroenterology, Hospital Universitario de Caceres, Caceres, Spain. Electronic address: pmataromero@gmail.com.
  • Martín-Holgado D; Department of Gastroenterology, Hospital Universitario de Caceres, Caceres, Spain.
  • Ferreira-Nossa HC; Department of Gastroenterology, Hospital Universitario de Caceres, Caceres, Spain.
  • González-Cordero PL; Department of Gastroenterology, Hospital Universitario de Caceres, Caceres, Spain.
  • Izquierdo-Martín A; Department of Pediatrics, Hospital San Pedro de Alcantara, Caceres, Spain.
  • Barros-García P; Department of Pediatrics, Hospital San Pedro de Alcantara, Caceres, Spain.
  • Fernandez-Gonzalez N; Department of Pathology, Hospital Universitario de Caceres, Caceres, Spain.
  • Fernández-Pereira L; Department of Immunology, Hospital San Pedro de Alcantara, Caceres, Spain.
  • Cámara-Hijón C; Department of Immunology, Hospital San Pedro de Alcantara, Caceres, Spain.
  • Molina-Infante J; Department of Gastroenterology, Hospital Universitario de Caceres, Caceres, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Gastroenterol Hepatol ; 45(9): 652-659, 2022 Nov.
Article en En, Es | MEDLINE | ID: mdl-35489585
BACKGROUND: Ultra-short coeliac disease (USCD) is a novel celiac disease (CD) subtype limited to the duodenal bulb (D1). HLA haplotypes and flow cytometry have not been assessed yet. AIMS: To compare genetic, clinical, serologic, histopathologic and inmmunophenotypic parameters between USCD and conventional celiac disease (CCD) patients. METHODS: Prospective single-center study in children and adult patients undergoing duodenal biopsies on a gluten-containing diet. Biopsies for histology and flow cytometry were taken separately from D1 and distal duodenum. Biopsies in seronegative patients with celiac lymphogram were repeated after 2 years on a gluten-free diet. RESULTS: Among 505 included patients, 127 were diagnosed with CD, of whom 7 (5.5%) showed USCD. HLADQ2 was significantly less common in USCD compared to CCD (71% vs. 95%, p 0.003). Likewise, USCD patients showed more frequent non-significant seronegativity (28% vs. 8%, p 0.07) and significantly lower titrations (7-15IU/ml) of tissue transglutaminase antibodies (tTG-IgA) (60% vs. 13%, p<0.001). Biopsies from D1 revealed significant less NK cells down-expression in USCD patients (1.4 vs. 5, p 0.04). CONCLUSIONS: Up to 5.5% of CD patients showed USCD. A lower frequency of HLADQ2, along with less serum tTG-IgA titration and duodenal NK cell suppression, were differential features of USCD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Celíaca Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Child / Humans Idioma: En / Es Revista: Gastroenterol Hepatol Año: 2022 Tipo del documento: Article Pais de publicación: España
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Celíaca Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Child / Humans Idioma: En / Es Revista: Gastroenterol Hepatol Año: 2022 Tipo del documento: Article Pais de publicación: España