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Alterations of white matter tracts and topological properties of structural networks in hemifacial spasm.
Wang, Jingqiang; Liu, Xiaoming; Wang, Xinyi; Hu, Yuhuan; Zeng, Qingrun; Lin, Zhicheng; Xiong, Nian; Feng, Yuanjing.
Afiliación
  • Wang J; Institution of Information Processing and Automation, College of Information Engineering, Zhejiang University of Technology, Hangzhou, China.
  • Liu X; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Wang X; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China.
  • Hu Y; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Zeng Q; Institution of Information Processing and Automation, College of Information Engineering, Zhejiang University of Technology, Hangzhou, China.
  • Lin Z; Institution of Information Processing and Automation, College of Information Engineering, Zhejiang University of Technology, Hangzhou, China.
  • Xiong N; Mclean Hospital, Harvard Medical School, Belmont, Massachusetts, USA.
  • Feng Y; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
NMR Biomed ; 35(9): e4756, 2022 09.
Article en En | MEDLINE | ID: mdl-35488376
Hemifacial spasm (HFS) is characterized by involuntary and paroxysmal muscle contractions on the hemiface. It is generally believed that HFS is caused by neurovascular compression at the root exit zone of the facial nerve. In recent years, the structural alterations of brains with HFS have aroused growing concern. However, little attention has been directed towards the possible involvement of specific white matter (WM) tracts and the topological properties of structural networks in HFS. In the present study, diffusion magnetic resonance imaging tractography was utilized to construct structural networks and perform tractometric analysis. The diffusion tensor imaging scalar parameters along with the WM tracts, and the topological parameters of global networks and subnetworks, were assessed in 62 HFS patients and 57 demographically matched healthy controls (HCs). Moreover, we investigated the correlation of these parameters with disease-clinical-level (DCL) and disease-duration-time (DDT) of HFS patients. Compared with HCs, HFS patients had additional hub regions including the amygdala, ventromedial putamen, lateral occipital cortex, and rostral cuneus gyrus. Furthermore, HFS patients showed significant alternations with specific topological properties in some structural subnetworks, including the limbic, default mode, dorsal attention, somato-motor, and control networks, as well as diffusion properties in some WM tracts, including the superior longitudinal fasciculus, cingulum bundle, thalamo-frontal, and corpus callosum. These subnetworks and tracts were associated with the regulation of emotion, motor function, vision, and attention. Notably, we also found that the parameters with subnetworks and tracts exhibited correlations with DCL and DDT. In addition to corroborating previous findings in HFS, this study demonstrates the changed microstructures in specific locations along with the fiber tracts and changed topological properties in structural subnetworks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espasmo Hemifacial / Sustancia Blanca Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: NMR Biomed Asunto de la revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espasmo Hemifacial / Sustancia Blanca Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: NMR Biomed Asunto de la revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido