Your browser doesn't support javascript.
loading
Apigenin attenuates molecular, biochemical, and histopathological changes associated with renal impairments induced by gentamicin exposure in rats.
Hussein, Manal M; Althagafi, Hussam A; Alharthi, Fahad; Albrakati, Ashraf; Alsharif, Khalaf F; Theyab, Abdulrahman; Kassab, Rami B; Mufti, Ahmad H; Algahtani, Mohammad; Oyouni, Atif Abdulwahab A; Baty, Roua S; Abdel Moneim, Ahmed E; Lokman, Maha S.
Afiliación
  • Hussein MM; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
  • Althagafi HA; Department of Biology, Faculty of Science and Arts, Al-Baha University, Al Makhwah, Al-Bahah, Saudi Arabia.
  • Alharthi F; Department of Biology, College of Science, Taif University, Taif, Saudi Arabia.
  • Albrakati A; Department of Human Anatomy, College of Medicine, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
  • Alsharif KF; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
  • Theyab A; College of Medicine, Al-Faisal University, Riyadh, Saudi Arabia.
  • Kassab RB; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt. ramikassab@mail.muni.cz.
  • Mufti AH; Department of Biology, Faculty of Science and Arts, Al-Baha University, Al Makhwah, Al-Bahah, Saudi Arabia. ramikassab@mail.muni.cz.
  • Algahtani M; Medical Genetics Department, Faculty of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
  • Oyouni AAA; Department of Laboratory Medicine, the Comprehensive Specialized Clinics of Security Forces, Jeddah, Saudi Arabia.
  • Baty RS; Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.
  • Abdel Moneim AE; Genome and Biotechnology Unit, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.
  • Lokman MS; Department of Biotechnology, College of Applied Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Environ Sci Pollut Res Int ; 29(43): 65276-65288, 2022 Sep.
Article en En | MEDLINE | ID: mdl-35484458
Gentamicin (GM) is an aminoglycoside antibiotic used to treat bacterial infections. However, its application is accompanied by renal impairments. Apigenin is a flavonoid found in many edible plants with potent therapeutic values. This study was designed to elucidate the therapeutic effects of apigenin on GM-induced nephrotoxicity. Animals were injected orally with three different doses of apigenin (5 mg kg-1 day-1, 10 mg kg-1 day-1, and 20 mg kg-1 day-1). Apigenin administration abolished the alterations in the kidney index and serum levels of kidney-specific functions markers, namely blood urea nitrogen and creatinine, and KIM-1, NGAL, and cystatin C following GM exposure. Additionally, apigenin increased levels of enzymatic (glutathione reductase, glutathione peroxidase, superoxide dismutase, and catalase) and non-enzymatic antioxidant proteins (reduced glutathione) and decreased levels of lipid peroxide, nitric oxide, and downregulated nitric oxide synthase-2 in the kidney tissue following GM administration. At the molecular scope, apigenin administration was found to upregulate the mRNA expression of Nfe2l2 and Hmox1 in the kidney tissue. Moreover, apigenin administration suppressed renal inflammation and apoptosis by decreasing levels of interleukin-1ß, tumor necrosis factor-alpha, nuclear factor kappa-B, Bax, and caspase-3, while increasing B-cell lymphoma-2 compared with those in GM-administered group. The recorded data suggests that apigenin treatment could be used to alleviate renal impairments associated with GM administration.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gentamicinas / Antioxidantes Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gentamicinas / Antioxidantes Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania