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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Stevens, Laura J; Pruijssers, Andrea J; Lee, Hery W; Gordon, Calvin J; Tchesnokov, Egor P; Gribble, Jennifer; George, Amelia S; Hughes, Tia M; Lu, Xiaotao; Li, Jiani; Perry, Jason K; Porter, Danielle P; Cihlar, Tomas; Sheahan, Timothy P; Baric, Ralph S; Götte, Matthias; Denison, Mark R.
Afiliación
  • Stevens LJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Pruijssers AJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Lee HW; Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN 37232, USA.
  • Gordon CJ; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada.
  • Tchesnokov EP; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada.
  • Gribble J; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada.
  • George AS; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Hughes TM; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Lu X; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Li J; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Perry JK; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Porter DP; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Cihlar T; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Sheahan TP; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Götte M; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Denison MR; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada.
Sci Transl Med ; 14(656): eabo0718, 2022 08 03.
Article en En | MEDLINE | ID: mdl-35482820
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / ARN Polimerasa Dependiente del ARN / Farmacorresistencia Viral / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / ARN Polimerasa Dependiente del ARN / Farmacorresistencia Viral / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos