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Development of core outcome sets for clinical trials in temporomandibular disorders: A study protocol.
Ferreira, Natália Dos Reis; Marto, Carlos Miguel Machado; de Oliveira, Aleli Tôrres; Rodrigues, Maria João; DosSantos, Marcos Fabio.
Afiliación
  • Ferreira NDR; Faculty of Medicine, Institute for Occlusion and Orofacial Pain, University of Coimbra, Coimbra, Portugal.
  • Marto CMM; Postgraduate Program in Medicine (Radiology), Faculty of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
  • de Oliveira AT; Faculty of Medicine, Institute of Experimental Pathology, University of Coimbra, Coimbra, Portugal.
  • Rodrigues MJ; Coimbra Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, Portugal.
  • DosSantos MF; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.
PLoS One ; 17(4): e0267722, 2022.
Article en En | MEDLINE | ID: mdl-35482750
BACKGROUND: Temporomandibular Disorder (TMD) is a generic term applied to describe musculoskeletal disorders that affect the temporomandibular joint (TMJ), the masticatory muscles and the related structures. TMD comprises two groups of disorders, namely intra-articular TMD and masticatory muscle disorders. There is still difficulty in establishing the effectiveness of different therapeutic modalities for TMD with robust evidence, despite the large volume of publications in the area. The lack of outcomes standardization may represent a limiting factor in the search for scientific evidence. OBJECTIVE: This study aims to develop a core outcome sets (COS) for clinical trials in intra-articular TMD and masticatory muscle disorders. METHODS: The protocol for determining the COS-TMD will consist of three phases: 1. Synthesis of TMD Management Intervention Outcomes. The identification of outcomes will be carried out through a systematic review, which will include randomized clinical trials that evaluated the effectiveness of interventions used in TMD management. 2. Through a two-round international Delphi survey, the list of outcomes will be scored by three panels of stakeholders. 3. A representative sample of key stakeholders will be invited to participate in a face-to-face meeting where they can discuss the results of the Delphi survey and determine the final core set. CONCLUSIONS: The implementation of this protocol will determine the COS-TMD, which will be made available for use in all TMD clinical studies. The use of COS when planning and reporting TMD clinical trials will reduce the risk of publication bias and enable proper comparison of results found by different studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Articulación Temporomandibular Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Qualitative_research / Systematic_reviews Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Articulación Temporomandibular Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Qualitative_research / Systematic_reviews Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos