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A loss-of-function polymorphism in ATG16L1 compromises therapeutic outcome in head and neck carcinoma patients.
Le Naour, Julie; Sztupinszki, Zsofia; Carbonnier, Vincent; Casiraghi, Odile; Marty, Virginie; Galluzzi, Lorenzo; Szallasi, Zoltan; Kroemer, Guido; Vacchelli, Erika.
Afiliación
  • Le Naour J; Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Institut Universitaire de France, Paris, France.
  • Sztupinszki Z; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
  • Carbonnier V; Université Paris Sud, Paris Saclay, Faculty of Medicine Kremlin Bicêtre, France.
  • Casiraghi O; Computational Health Informatics Program (CHIP), Boston Children's Hospital, Boston, MA, USA.
  • Marty V; Harvard Medical School, Boston, MA, USA.
  • Galluzzi L; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Szallasi Z; Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Institut Universitaire de France, Paris, France.
  • Kroemer G; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
  • Vacchelli E; Université Paris Sud, Paris Saclay, Faculty of Medicine Kremlin Bicêtre, France.
Oncoimmunology ; 11(1): 2059878, 2022.
Article en En | MEDLINE | ID: mdl-35481288
The anticancer immune response is shaped by immunogenic cell stress and death pathways. Thus, cancer cells can release danger-associated molecular patterns that act on pattern recognition receptors expressed by dendritic cells and their precursors to elicit an antitumor immune response. Here, we investigated the impact of single nucleotide polymorphisms (SNPs) in genes affecting this cancer-immunity dialogue in the context of head and neck squamous cell carcinoma (HNSCC). We observed that homozygosity for a loss-of-function SNP (rs2241880, leading to the substitution of a threonine residue in position 300 by an alanine) affecting autophagy related 16 like 1 (ATG16L1) is coupled to poor progression-free survival in platinum-treated HNSCC patients. This result was obtained on a cohort of patients enrolled at the Gustave Roussy Cancer Campus and was validated on an independent cohort of The Cancer Genome Atlas (TCGA). Homozygosity in rs2241880 is well known to predispose to Crohn's disease, and epidemiological associations between Crohn's disease and HNSCC have been reported at the levels of cancer incidence and prognosis. We speculate that rs2241880 might be partially responsible for this association.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Crohn / Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Oncoimmunology Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Crohn / Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Oncoimmunology Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos