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Comparative Analysis of Adult Patients With Idiopathic Pulmonary Hemosiderosis and Lane-Hamilton Syndrome: A Systematic Review of the Literature in the Period 1971-2022.
Saha, Biplab K; Datar, Praveen; Aiman, Alexis; Bonnier, Alyssa; Saha, Santu; Milman, Nils T.
Afiliación
  • Saha BK; Pulmonary and Critical Care Medicine, Ozarks Medical Center, West Plains, USA.
  • Datar P; Pulmonary and Critical Care Medicine, Ozarks Medical Center, West Plains, USA.
  • Aiman A; Internal Medicine, New York Institute of Technology College of Osteopathic Medicine at Arkansas State University, Jonesboro, USA.
  • Bonnier A; Critical Care, Goldfarb School of Nursing at Barnes Jewish College, Saint Louis, USA.
  • Saha S; Internal Medicine, Saha Clinic, Narail, BGD.
  • Milman NT; Pulmonary and Critical Care, University College Zealand, Næstved, DNK.
Cureus ; 14(3): e23482, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35475077
Idiopathic pulmonary hemosiderosis (IPH) causes diffuse alveolar hemorrhage (DAH) by a yet unknown mechanism. The coexistence of IPH and celiac disease (CD), also known as Lane-Hamilton syndrome (LHS), has been reported in both pediatric and adult patients. The objective of this study was to compare demographics, clinical and radiologic findings, treatment, and outcomes between adult patients with IPH and LHS. This is a systematic review of the literature. Multiple databases were searched using appropriate formulas to identify relevant articles. A total of 60 studies reporting 65 patients were included in the review. Forty-nine of these patients had IPH and 16 had LHS. The prevalence of anti-CD antibodies among tested patients was 13/22 (59%). The symptom onset and diagnosis of IPH occurred earlier in patients with LHS. The median delay in diagnosis was the same between the two groups (52 weeks). The classic triad was more likely to be present in patients with LHS. Only 20% of patients in the LHS cohort had any significant gastrointestinal (GI) symptoms at the time of IPH diagnosis. A gluten-free diet alone was effective in the majority of patients. Fewer patients in the LHS cohort received systemic corticosteroid than the IPH cohort. The recurrence and mortality in patients with LHS appear to be less than in the IPH cohort. The prevalence of CD is 25% in adult patients with IPH. Patients with LHS may have a milder course than patients without CD. Serologic testing for CD should be performed in all patients diagnosed with IPH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Cureus Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Cureus Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos