Pharmacodynamic evaluation of the XOR inhibitor WN1703 in a model of chronic hyperuricemia in rats induced by yeast extract combined with potassium oxonate.

Li, Yuanyuan; Zhu, Xinying; Liu, Fuyao; Peng, Wen; Zhang, Lei; Li, Jing

Li, Yuanyuan; Zhu, Xinying; Liu, Fuyao; Peng, Wen; Zhang, Lei; Li, Jing.

Afiliación

Li Y; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Zhu X; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Liu F; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Peng W; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Zhang L; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Li J; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.

Curr Res Pharmacol Drug Discov ; 3: 100098, 2022.

Article en En | MEDLINE | ID: mdl-35465446

Palabras clave

ADA, adenosine deaminase; BUN, blood urea nitrogen; CG, control group; CMC-Na, sodium carboxymethyl cellulose; FEB, febuxostat; Febuxostat; GSH-PX, glutathione peroxidase; H1703, high dose of WN1703; Hyperuricemia; IL-1ß, interleukin-1ß; L1703, low dose of WN1703; M1703, median dose of WN1703; MCP, monocyte chemoattractant protein; MG, model group; Rat model; TNF-α, tumor necrosis factor-α; UA, uric acid; URAT1, urate transport protein 1; Uric acid; XOR inhibitor; XOR, xanthine oxidoreductase; YEP, yeast extract paste

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Curr Res Pharmacol Drug Discov Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos

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