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The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections.
Hsu, Ren-Jun; Yu, Wei-Chieh; Peng, Guan-Ru; Ye, Chih-Hung; Hu, SuiYun; Chong, Patrick Chun Theng; Yap, Kah Yi; Lee, Jamie Yu Chieh; Lin, Wei-Chen; Yu, Shu-Han.
Afiliación
  • Hsu RJ; Cancer Center, Hualien Tzu Chi Hospital, Buddhist Tzuchi Medical Foundation, Hualien, Taiwan.
  • Yu WC; School of Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan.
  • Peng GR; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
  • Ye CH; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
  • Hu S; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
  • Chong PCT; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
  • Yap KY; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
  • Lee JYC; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
  • Lin WC; University of California, Los Angeles, Los Angeles, CA, United States.
  • Yu SH; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Front Immunol ; 13: 832394, 2022.
Article en En | MEDLINE | ID: mdl-35464491
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless infections and caused millions of deaths since its emergence in 2019. Coronavirus disease 2019 (COVID-19)-associated mortality is caused by uncontrolled inflammation, aberrant immune response, cytokine storm, and an imbalanced hyperactive immune system. The cytokine storm further results in multiple organ failure and lung immunopathology. Therefore, any potential treatments should focus on the direct elimination of viral particles, prevention strategies, and mitigation of the imbalanced (hyperactive) immune system. This review focuses on cytokine secretions of innate and adaptive immune responses against COVID-19, including interleukins, interferons, tumor necrosis factor-alpha, and other chemokines. In addition to the review focus, we discuss potential immunotherapeutic approaches based on relevant pathophysiological features, the systemic immune response against SARS-CoV-2, and data from recent clinical trials and experiments on the COVID-19-associated cytokine storm. Prompt use of these cytokines as diagnostic markers and aggressive prevention and management of the cytokine storm can help determine COVID-19-associated morbidity and mortality. The prophylaxis and rapid management of the cytokine storm appear to significantly improve disease outcomes. For these reasons, this study aims to provide advanced information to facilitate innovative strategies to survive in the COVID-19 pandemic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza