Your browser doesn't support javascript.
loading
Baseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: results from the COVID-19 global rheumatology alliance vaccine survey.
Rider, Lisa G; Parks, Christine G; Wilkerson, Jesse; Schiffenbauer, Adam I; Kwok, Richard K; Noroozi Farhadi, Payam; Nazir, Sarvar; Ritter, Rebecca; Sirotich, Emily; Kennedy, Kevin; Larche, Maggie J; Levine, Mitchell; Sattui, Sebastian E; Liew, Jean W; Harrison, Carly O; Moni, Tarin T; Miller, Aubrey K; Putman, Michael; Hausmann, Jonathan; Simard, Julia F; Sparks, Jeffrey A; Miller, Frederick W.
Afiliación
  • Rider LG; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Bethesda, MD.
  • Parks CG; Epidemiology Branch, NIEHS, NIH, Research Triangle Park.
  • Wilkerson J; Social Scientific Systems, Durham.
  • Schiffenbauer AI; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Bethesda, MD.
  • Kwok RK; Office of the Director, NIEHS, NIH, Research Triangle Park, NC, USA.
  • Noroozi Farhadi P; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Bethesda, MD.
  • Nazir S; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Bethesda, MD.
  • Ritter R; Social Scientific Systems, Durham.
  • Sirotich E; Department of Medicine, McMaster University.
  • Kennedy K; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, ON, Canada.
  • Larche MJ; Department of Medicine, McMaster University.
  • Levine M; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, ON, Canada.
  • Sattui SE; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
  • Liew JW; Section of Rheumatology, Boston University School of Medicine, Boston, MA.
  • Harrison CO; LupusChat, New York, NY, USA.
  • Moni TT; Department of Biochemistry and Biomedical Sciences, McMaster University Faculty of Science, Hamilton, ON, Canada.
  • Miller AK; Office of the Director, NIEHS, NIH, Research Triangle Park, NC, USA.
  • Putman M; Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI.
  • Hausmann J; Program in Rheumatology, Boston Children's Hospital, Division of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA.
  • Simard JF; Department of Epidemiology and Population Health, and Immunology and Rheumatology (Department of Medicine), Stanford University School of Medicine.
  • Sparks JA; Division of Rheumatology, Immunology, Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Miller FW; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Bethesda, MD.
Rheumatology (Oxford) ; 61(SI2): SI143-SI150, 2022 06 28.
Article en En | MEDLINE | ID: mdl-35460240
OBJECTIVE: To examine the frequency of, and risk factors for, disease flare following COVID-19 vaccination in patients with systemic rheumatic disease (SRD). METHODS: An international study was conducted from 2 April to 16 August 2021, using an online survey of 5619 adults with SRD for adverse events following COVID-19 vaccination, including flares of disease requiring a change in treatment. We examined risk factors identified a priori based on published associations with SRD activity and SARS-CoV-2 severity, including demographics, SRD type, comorbidities, vaccine type, cessation of immunosuppressive medications around vaccination and history of reactions to non-COVID-19 vaccines, using multivariable logistic regression. RESULTS: Flares requiring a change in treatment following COVID-19 vaccination were reported by 4.9% of patients. Compared with rheumatoid arthritis, certain SRD, including systemic lupus erythematosus (OR 1.51, 95% CI 1.03, 2.20), psoriatic arthritis (OR 1.95, 95% CI 1.20, 3.18) and polymyalgia rheumatica (OR 1.94, 95% CI 1.08, 2.48) were associated with higher odds of flare, while idiopathic inflammatory myopathies were associated with lower odds for flare (OR 0.54, 95% CI 0.31-0.96). The Oxford-AstraZeneca vaccine was associated with higher odds of flare relative to the Pfizer-BioNTech vaccine (OR 1.44, 95% CI 1.07, 1.95), as were a prior reaction to a non-COVID-19 vaccine (OR 2.50, 95% CI 1.76, 3.54) and female sex (OR 2.71, 95% CI 1.55, 4.72). CONCLUSION: SRD flares requiring changes in treatment following COVID-19 vaccination were uncommon in this large international study. Several potential risk factors, as well as differences by disease type, warrant further examination in prospective cohorts.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Reumáticas / Vacunas contra la COVID-19 / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Reumáticas / Vacunas contra la COVID-19 / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido