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In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts.
Fofana, Souleymane; Delporte, Cédric; Calvo Esposito, Rafaèle; Ouédraogo, Moussa; Van Antwerpen, Pierre; Guissou, Innocent Pierre; Semdé, Rasmané; Mathieu, Véronique.
Afiliación
  • Fofana S; Laboratory of Drug Sciences, Higher Institute of Health Sciences (INSSA), Nazi BONI University, Bobo-Dioulasso 01 P.O. Box 1091, Burkina Faso.
  • Delporte C; RD3-Pharmacognosy, Bioanalysis and Drug Discovery Unit and Analytical Platform, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium.
  • Calvo Esposito R; Protein Chemistry Unit, Department of General Chemistry I, Faculty of Medicine, Université Libre de Bruxelles, Campus Erasme (CP 609), Route de Lennik, 1070 Brussels, Belgium.
  • Ouédraogo M; Department of Pharmacotherapy and Pharmaceuticals, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium.
  • Van Antwerpen P; Laboratory of Drug Development (LADME), Center of Training, Research and Expertises of Pharmaceutical Sciences (CEA-CFOREM), Training and Research Unit, Health Sciences, Joseph KI-ZERBO University, Ouagadougou 03 P.O. Box 7021, Burkina Faso.
  • Guissou IP; RD3-Pharmacognosy, Bioanalysis and Drug Discovery Unit and Analytical Platform, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium.
  • Semdé R; Faculty of Health Sciences, Saint Thomas d'Aquin University, Ouagadougou 06 P.O. Box 10212, Burkina Faso.
  • Mathieu V; Laboratory of Drug Development (LADME), Center of Training, Research and Expertises of Pharmaceutical Sciences (CEA-CFOREM), Training and Research Unit, Health Sciences, Joseph KI-ZERBO University, Ouagadougou 03 P.O. Box 7021, Burkina Faso.
Molecules ; 27(8)2022 Apr 16.
Article en En | MEDLINE | ID: mdl-35458781
Although Erythrina senegalensis is a plant widely used in traditional medicine in sub-Saharan Africa, its biological properties have been poorly investigated to date. We first characterized by conventional reactions the composition of several stem bark extracts and evaluated in acellular and cellular assays their pro- or antioxidant properties supported by their high phenolic and flavonoid content, particularly with the methanolic extract. The pro- or antioxidant effects observed did not correlate with their IC50 concentrations against five cancer cell lines determined by MTT assay. Indeed, the CH2Cl2 extract and its ethyl acetate (EtOAc) subfraction appeared more potent although they harbored lower pro- or antioxidant effects. Nevertheless, at equipotent concentration, both extracts induced ER- and mitochondria-derived vacuoles observed by fluorescent microscopy that further led to non-apoptotic cell death. LC coupled to high resolution MS investigations have been performed to identify chemical compounds of the extracts. These investigations highlighted the presence of compounds formerly isolated from E. senegalensis including senegalensein that could be retrieved only in the EtOAc subfraction but also thirteen other compounds, such as 16:3-Glc-stigmasterol and hexadecanoic acid, whose anticancer properties have been previously reported. Nineteen other compounds remain to be identified. In conclusion, E. senegalensis appeared rich in compounds with antioxidant and anticancer properties, supporting its use in traditional practice and its status as a species of interest for further investigations in anticancer drug research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Erythrina / Antioxidantes Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Burquina Faso Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Erythrina / Antioxidantes Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Burquina Faso Pais de publicación: Suiza