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The Complexity of Sesquiterpene Chemistry Dictates Its Pleiotropic Biologic Effects on Inflammation.
Arizmendi, Narcy; Alam, Syed Benazir; Azyat, Khalid; Makeiff, Darren; Befus, A Dean; Kulka, Marianna.
Afiliación
  • Arizmendi N; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB T6G 2A3, Canada.
  • Alam SB; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB T6G 2A3, Canada.
  • Azyat K; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB T6G 2A3, Canada.
  • Makeiff D; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB T6G 2A3, Canada.
  • Befus AD; Alberta Respiratory Centre, Department of Medicine, Faculty of Medicine, University of Alberta, Edmonton, AB T6G 2E1, Canada.
  • Kulka M; Nanotechnology Research Centre, National Research Council Canada, Edmonton, AB T6G 2A3, Canada.
Molecules ; 27(8)2022 Apr 11.
Article en En | MEDLINE | ID: mdl-35458648
Sesquiterpenes (SQs) are volatile compounds made by plants, insects, and marine organisms. SQ have a large range of biological properties and are potent inhibitors and modulators of inflammation, targeting specific components of the nuclear factor-kappaB (NF-κB) signaling pathway and nitric oxide (NO) generation. Because SQs can be isolated from over 1600 genera and 2500 species grown worldwide, they are an attractive source of phytochemical therapeutics. The chemical structure and biosynthesis of SQs is complex, and the SQ scaffold represents extraordinary structural variety consisting of both acyclic and cyclic (mono, bi, tri, and tetracyclic) compounds. These structures can be decorated with a diverse range of functional groups and substituents, generating many stereospecific configurations. In this review, the effect of SQs on inflammation will be discussed in the context of their complex chemistry. Because inflammation is a multifactorial process, we focus on specific aspects of inflammation: the inhibition of NF-kB signaling, disruption of NO production and modulation of dendritic cells, mast cells, and monocytes. Although the molecular targets of SQs are varied, we discuss how these pathways may mediate the effects of SQs on inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Lipopolisacáridos / Inflamación Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Lipopolisacáridos / Inflamación Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza