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Schizophrenia and Bipolar Polygenic Risk Scores in Relation to Intracranial Volume.
de Zwarte, Sonja M C; Brouwer, Rachel M; Kahn, René S; van Haren, Neeltje E M.
Afiliación
  • de Zwarte SMC; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CG Utrecht, The Netherlands.
  • Brouwer RM; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CG Utrecht, The Netherlands.
  • Kahn RS; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
  • van Haren NEM; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CG Utrecht, The Netherlands.
Genes (Basel) ; 13(4)2022 04 14.
Article en En | MEDLINE | ID: mdl-35456501
Schizophrenia and bipolar disorder are neurodevelopmental disorders with overlapping symptoms and a shared genetic background. Deviations in intracranial volume (ICV)­a marker for neurodevelopment­differ between schizophrenia and bipolar disorder. Here, we investigated whether genetic risk for schizophrenia and bipolar disorder is related to ICV in the general population by using the UK Biobank data (n = 20,196). Polygenic risk scores for schizophrenia (SZ-PRS) and bipolar disorder (BD-PRS) were computed for 12 genome wide association study P-value thresholds (PT) for each individual and correlations with ICV were investigated. Partial correlations were performed at each PT to investigate whether disease specific genetic risk variants for schizophrenia and bipolar disorder show different relationships with ICV. ICV showed a negative correlation with SZ-PRS at PT ≥ 0.005 (r < −0.02, p < 0.005). ICV was not associated with BD-PRS; however, a positive correlation between BD-PRS and ICV at PT = 0.2 and PT = 0.4 (r = +0.02, p < 0.005) appeared when the genetic overlap between schizophrenia and bipolar disorder was accounted for. Despite small effect sizes, a higher load of schizophrenia risk genes is associated with a smaller ICV in the general population, while risk genes specific for bipolar disorder are correlated with a larger ICV. These findings suggest that schizophrenia and bipolar disorder risk genes, when accounting for the genetic overlap between both disorders, have opposite effects on early brain development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Genes (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Genes (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza