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Is Nucleoredoxin a Master Regulator of Cellular Redox Homeostasis? Its Implication in Different Pathologies.
Idelfonso-García, Osiris Germán; Alarcón-Sánchez, Brisa Rodope; Vásquez-Garzón, Verónica Rocío; Baltiérrez-Hoyos, Rafael; Villa-Treviño, Saúl; Muriel, Pablo; Serrano, Héctor; Pérez-Carreón, Julio Isael; Arellanes-Robledo, Jaime.
Afiliación
  • Idelfonso-García OG; Laboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.
  • Alarcón-Sánchez BR; Department of Health Sciences, Metropolitan Autonomous University-Iztapalapa Campus, Mexico City 09340, Mexico.
  • Vásquez-Garzón VR; Laboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.
  • Baltiérrez-Hoyos R; Department of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPN, Mexico City 07360, Mexico.
  • Villa-Treviño S; Laboratory of Fibrosis and Cancer, Faculty of Medicine and Surgery, 'Benito Juárez' Autonomous University of Oaxaca-UABJO, Oaxaca 68020, Mexico.
  • Muriel P; Directorate of Cátedras, National Council of Science and Technology-CONACYT, Mexico City 03940, Mexico.
  • Serrano H; Laboratory of Fibrosis and Cancer, Faculty of Medicine and Surgery, 'Benito Juárez' Autonomous University of Oaxaca-UABJO, Oaxaca 68020, Mexico.
  • Pérez-Carreón JI; Directorate of Cátedras, National Council of Science and Technology-CONACYT, Mexico City 03940, Mexico.
  • Arellanes-Robledo J; Department of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPN, Mexico City 07360, Mexico.
Antioxidants (Basel) ; 11(4)2022 Mar 30.
Article en En | MEDLINE | ID: mdl-35453355
Nucleoredoxin (NXN), an oxidoreductase enzyme, contributes to cellular redox homeostasis by regulating different signaling pathways in a redox-dependent manner. By interacting with seven proteins so far, namely disheveled (DVL), protein phosphatase 2A (PP2A), phosphofructokinase-1 (PFK1), translocation protein SEC63 homolog (SEC63), myeloid differentiation primary response gene-88 (MYD88), flightless-I (FLII), and calcium/calmodulin-dependent protein kinase II type alpha (CAMK2A), NXN is involved in the regulation of several key cellular processes, including proliferation, organogenesis, cell cycle progression, glycolysis, innate immunity and inflammation, motility, contraction, protein transport into the endoplasmic reticulum, neuronal plasticity, among others; as a result, NXN has been implicated in different pathologies, such as cancer, alcoholic and polycystic liver disease, liver fibrogenesis, obesity, Robinow syndrome, diabetes mellitus, Alzheimer's disease, and retinitis pigmentosa. Together, this evidence places NXN as a strong candidate to be a master redox regulator of cell physiology and as the hub of different redox-sensitive signaling pathways and associated pathologies. This review summarizes and discusses the current insights on NXN-dependent redox regulation and its implication in different pathologies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2022 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2022 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza