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Subsequent malignant neoplasms in the pediatric age in retinoblastoma survivors in Argentina.
Villanueva, Gabriela; Sampor, Claudia; Moreno, Florencia; Alderete, Daniel; Moresco, Angelica; Pinto, Natalia; Szijan, Irene; Schaiquevich, Paula; Felice, María Sara; Rose, Adriana; Zubizarreta, Pedro; Sgroi, Mariana; Fandiño, Adriana; Chantada, Guillermo.
Afiliación
  • Villanueva G; Hematology and Oncology Department, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Sampor C; Hematology and Oncology Department, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Moreno F; Instituto Nacional del Cáncer, Registro Onco-pediatrico Hospitalario Argentino (ROHA), Buenos Aires, Argentina.
  • Alderete D; Hematology and Oncology Department, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Moresco A; Department of Genetics, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Pinto N; Department of Radiotherapy, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Szijan I; Cátedra de Genética, Facultad de Farmacia y Bioquímica, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
  • Schaiquevich P; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
  • Felice MS; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
  • Rose A; Hematology and Oncology Department, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Zubizarreta P; Hematology and Oncology Department, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Sgroi M; Hematology and Oncology Department, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Fandiño A; Ophthalmology Department, Hospital JP Garrahan, Buenos Aires, Argentina.
  • Chantada G; Ophthalmology Department, Hospital JP Garrahan, Buenos Aires, Argentina.
Pediatr Blood Cancer ; 69(8): e29710, 2022 08.
Article en En | MEDLINE | ID: mdl-35451226
BACKGROUND: Retinoblastoma survivors in low- and middle-income countries are exposed to high-intensity treatments that potentially place them at higher risk of early subsequent malignant neoplasms (SMNs). METHODS: We followed 714 (403 [56.4%] nonhereditary and 311 [43.5%] hereditary) retinoblastoma survivors diagnosed from August 1987 to December 2016, up to the age of 16 years. We quantified risk of SMNs with cumulative incidence (CI) and standardized incidence ratios (SIR) analysis. Multivariate regression Cox model was used to determine the association of treatments and risk of SMNs. RESULTS: Median follow-up was of 9 years (range: 0.18-16.9) and 24 survivors (3.36%) developed 25 SMNs (n = 22 hereditary, n = 2 nonhereditary). SMNs included sarcomas (osteosarcomas, Ewing sarcomas, rhabdomyosarcomas; n = 12), leukemias (n = 5), and central nervous system tumors (CNS; n = 3). All cases of acute myeloid leukemia (AML) and most of Ewing sarcomas occurred within 5 years of retinoblastoma diagnosis. The type of SMN was the main indicator of mortality (five of five patients with leukemias, six of 12 with sarcomas, and zero of three with CNS tumors died). Compared to the general population, radiation increased the risk of Ewing sarcoma in hereditary survivors by 700-fold (95% CI = 252-2422.6) and chemotherapy increased the risk of AML by 140-fold (95% CI = 45.3-436). The CI of SMNs for hereditary survivors was 13.7% (95% CI = 8.4-22.1) at 15 years. CONCLUSION: Retinoblastoma survivors from Argentina are at higher risk of developing SMNs early in life compared to the general Argentinean population, especially those treated with radiation plus chemotherapy. AML and Ewing sarcoma presented within 5 years of retinoblastoma diagnosis are associated with chemotherapy and radiation exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retinoblastoma / Sarcoma / Sarcoma de Ewing / Neoplasias Cutáneas / Neoplasias de los Tejidos Blandos / Neoplasias Óseas / Neoplasias de la Mama / Leucemia / Neoplasias Primarias Secundarias / Neoplasias del Sistema Nervioso Central Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans País/Región como asunto: America do sul / Argentina Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retinoblastoma / Sarcoma / Sarcoma de Ewing / Neoplasias Cutáneas / Neoplasias de los Tejidos Blandos / Neoplasias Óseas / Neoplasias de la Mama / Leucemia / Neoplasias Primarias Secundarias / Neoplasias del Sistema Nervioso Central Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans País/Región como asunto: America do sul / Argentina Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Estados Unidos