Your browser doesn't support javascript.
loading
Adherence to Antiretroviral Therapy by Medication Possession Ratio and Virological Suppression among Adolescents and Young Adults Living with HIV in Dar es Salaam, Tanzania.
Amour, Maryam; Sangeda, Raphael Z; Kidenya, Benson; Balandya, Emmanuel; Mmbaga, Blandina T; Machumi, Lameck; Rugarabamu, Angelica; Aris, Eric; Njiro, Belinda J; Ndumwa, Harrieth P; Lyamuya, Eligius; Sunguya, Bruno F.
Afiliación
  • Amour M; Department of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
  • Sangeda RZ; Department of Pharmaceutical Microbiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
  • Kidenya B; Catholic University of Health and Allied Sciences, Bugando, Mwanza P.O. Box 1464, Tanzania.
  • Balandya E; Department of Physiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
  • Mmbaga BT; Kilimanjaro Christian Medical University College, Moshi P.O. Box 3010, Tanzania.
  • Machumi L; Kilimanjaro Clinical Research Institute, Moshi P.O. Box 2236, Tanzania.
  • Rugarabamu A; Management and Development for Health, Dar es Salaam P.O. Box 79810, Tanzania.
  • Aris E; Management and Development for Health, Dar es Salaam P.O. Box 79810, Tanzania.
  • Njiro BJ; Management and Development for Health, Dar es Salaam P.O. Box 79810, Tanzania.
  • Ndumwa HP; Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
  • Lyamuya E; Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
  • Sunguya BF; Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania.
Trop Med Infect Dis ; 7(4)2022 Mar 24.
Article en En | MEDLINE | ID: mdl-35448827
Background: Adherence to antiretroviral therapy (ART) is a strong determinant of virological suppression. We aimed to determine the magnitude of adherence as measured by medication possession ratio (MPR) and virological suppression with its predictors among adolescents and young adults (AYA) living with HIV on ART in Tanzania. Methods: This retrospective cohort study was conducted using archived data from HIV care and treatment centers in Dar es Salaam, Tanzania between 2015 and 2019. The logistic regression model assessed predictors for adherence and virological suppression. Results: Data of 5750 AYA living with HIV were analysed. The majority were females: 4748 (82.6%). About 63% had good adherence with MPR ≥ 85% at one year post ART initiation. Independent predictors of ART adherence were male sex (aOR = 1.3, 95% CI 1.1−1.5), CD4 > 500 cells/mm3 (aOR = 0.7, 95% CI: 0.6−0.9), WHO stage III (aOR = 1.6, 95% CI 1.3−1.9), enrollment in 2019 (aOR = 1.5, 95% CI 1.2−1.9), and virological suppression (aOR = 2.0, 95% CI 1.6−2.9). Using an Efavirenz- and a Nevirapine-based combination was associated with reduced odds of ART adherence (aOR = 0.3, 95% CI 0.1−0.8) and (aOR = 0.2, 95% CI 0.1−0.6), respectively. Predictors of virological suppression were MPR ≥ 85% (aOR = 2.0, 95% CI 1.6−2.4); CD4 > 500 cells/mm3 (aOR = 2.4, 95% CI 1.7−3.4), and once-daily dosing (aOR = 2.0, 95% CI 1.3−2.5). Conclusion: Adherence to ART among AYA living with HIV is suboptimal. Sex, year of enrollment, ART drug combination used, and immunological status at ART initiation are important predictors of adherence to ART and virological suppression.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Trop Med Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Tanzania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Trop Med Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Tanzania Pais de publicación: Suiza