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Prognostic value of radial peripapillary capillary density for visual field outcomes in pituitary adenoma: A case-control study.
Tang, Yang; Jia, Wang; Xue, Zhan; Yuan, Linhao; Qu, Yuanzhen; Yang, Liu; Wang, Lina; Ma, Xiaochen; Wang, Meizi; Meng, Lei; Lei, Kun; Lu, Wen; Peng, Xiaoyan.
Afiliación
  • Tang Y; Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China; Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, 8 Chongwenmen Nei Dajie, Dongcheng District, Beijing 100005, China.
  • Jia W; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China; Beijing Neurosurgical Institute, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Xue Z; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Yuan L; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Qu Y; Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Yang L; Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Wang L; Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Ma X; Beijing Center for Disease Prevention and Control, 16 Hepingli Middle Street, Dongcheng District, Beijing 100013, China.
  • Wang M; Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Meng L; Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Lei K; Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Lu W; Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuanxilu, Fengtai District, Beijing 100070, China.
  • Peng X; Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, 8 Chongwenmen Nei Dajie, Dongcheng District, Beijing 100005, China; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing 100041, China. Electronic address: 74000041@ccmu.edu.cn.
J Clin Neurosci ; 100: 113-119, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35447509
Pituitary adenomas are known to cause optic chiasmal compression leading to visual field (VF) defects. Herein, we analysed the factors influencing early VF recovery following transsphenoidal surgery and explored the significance of retinal vessel density parameters in predicting prognoses. We collected data of 50 patients with pituitary adenoma and an abnormal VF prior to surgery. Patients were categorised into VF recovery (n = 25) and non-recovery (n = 25) groups within 1 week postoperatively. The VF, optic chiasm form, tumour volume, retinal thickness, and vessel density parameters were measured. The χ2 test was used for single-factor analyses, and odds ratios (ORs) for each factor were calculated. Logistic regression was implemented to determine interactions between radial peripapillary capillary (RPC) density and other factors. Tumour volume (≥5 cm3, OR = 5.09), duration of visual symptoms (≥6 months, OR = 6.00), preoperative VF (mean deviation [MD] < -10 dB, OR = 6.77), thin retinal nerve fibre layer (OR = 9.04), ganglion cell layer complex thickness (OR = 7.67), and RPC density (whole ≤ 48%; OR = 15.58; temporal ≤ 49.3%; OR = 14.64) were found to be risk factors for postoperative VF recovery. After adjusting for these factors, RPC density was a dependent factor affecting VF recovery in patients with pituitary adenoma. RPC density seemed to be a stronger indicator than preoperative MD, tumour volume, duration of visual symptoms, or retinal thickness for predicting early VF recovery following optic chiasm decompression, thus helping surgeons determine the optimal timing of surgery and formulate effective treatment plans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias / Adenoma Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Clin Neurosci Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias / Adenoma Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Clin Neurosci Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido