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Wnt3a but not CDX-2 expression is associated with differentiated thyroid cancer.
Biagini, Gleyne Lopes Kujew; Ribas, Carmem Austrália Paredes Marcondes; Higashi, Henrique Diez; Hirata, Vanessa Yumi; Zella, Maria Augusta Karas; Bartolomei, Ivan; Biagini, Giuliana; Collaço, Luiz Martins.
Afiliación
  • Biagini GLK; Faculdade de Medicina da Escola Evangélica Mackenzie, Medical Research Institute - Curitiba (PR), Brazil.
  • Ribas CAPM; Faculdade de Medicina da Escola Evangélica Mackenzie, Medical Research Institute - Curitiba (PR), Brazil.
  • Higashi HD; Faculdade de Medicina da Escola Evangélica Mackenzie, Medical Research Institute - Curitiba (PR), Brazil.
  • Hirata VY; Faculdade de Medicina da Escola Evangélica Mackenzie, Medical Research Institute - Curitiba (PR), Brazil.
  • Zella MAK; Faculdade de Medicina da Escola Evangélica Mackenzie, Medical Research Institute - Curitiba (PR), Brazil.
  • Bartolomei I; Faculdade de Medicina da Escola Evangélica Mackenzie, Medical Research Institute - Curitiba (PR), Brazil.
  • Biagini G; Instituto Carlos Chagas, Fundação Oswaldo Cruz - Curitiba (PR), Brazil.
  • Collaço LM; Faculdade de Medicina da Escola Evangélica Mackenzie, Medical Research Institute - Curitiba (PR), Brazil.
Rev Assoc Med Bras (1992) ; 68(3): 400-404, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35442371
OBJECTIVE: Thyroid neoplasm incidence has increased worldwide, mostly due to the advancements in medical imaging and screening rates. The aberrant Wnt/ß-catenin pathway has been identified as a key mechanism, and it has also been related to the metastatic activity of differentiated thyroid cancer. We aimed to verify the difference in the expression of Wnt3a, a canonical activator of the ß-catenin signaling, and CDX-2, a transcription factor upregulated by Wnt/ß-catenin pathway, in multinodular goiter and differentiated thyroid cancer and to determine their prognostic value. METHODS: We included 194 thyroid tissue surgical specimen and their clinicopathological data: study group (differentiated thyroid cancer, n=154) and control group (multinodular goiter, n=40). Immunohistochemistry (IHC) was performed on formalin-fixed, paraffin-embedded tissue by the primary antibodies Wnt3a and CDX-2. RESULTS: High Wnt3a expression was significantly associated with differentiated thyroid cancer (p=0.031). CDX-2 was negative in all differentiated thyroid cancer cases (100%) and also in multinodular goiter. Wnt3a expression was significantly associated with tumors ≤20 mm (p=0.044) and with the absence of capsule invasion (p=0.031). The multivariate analyses suggested that older age (≥55), independent of capsular invasion and tumor size, was an independent prognostic factor for Wnt3a expression (p=0.058). CONCLUSIONS: Wnt3a expression but not CDX-2 is correlated with differentiated thyroid cancer samples in comparison to multinodular goiter. Although its prognostic value was limited to tumor size and capsule invasion, a combined model in a panel of immune markers can add accuracy in the classification of challenging thyroid follicular-derived lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Adenocarcinoma / Proteína Wnt3A Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Adenocarcinoma / Proteína Wnt3A Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil