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The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse.
Costa E Silva, C L; Bortolini, M A T; Batista, N C; Silva, R S P; Teixeira, J B; Oliveira, É; Souto, R P; Castro, R A.
Afiliación
  • Costa E Silva CL; Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Bortolini MAT; Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Batista NC; Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Silva RSP; Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Teixeira JB; Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Oliveira É; Department of Urogynecology and Vaginal Surgery, Centro Universitário FMABC, Santo André, Brazil.
  • Souto RP; Department of Morphology and Physiology, Centro Universitário FMABC, Santo André, Brazil.
  • Castro RA; Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.
Climacteric ; 25(4): 407-412, 2022 08.
Article en En | MEDLINE | ID: mdl-35440244
OBJECTIVE: This study aimed to verify the presence of polymorphism rs2165241 of the lysyl oxidase-like 1 (Loxl1) gene and its association with pelvic organ prolapse (POP) in Brazilian women and determine risk factors for POP development. METHODS: The study was previously approved by the local research and ethics board. Postmenopausal women were included and divided into POP (stages III and IV) and control (stages 0 and I) groups. Peripheral blood samples were collected, and the DNA sequence of interest was analyzed by real-time reverse-transcriptase polymerase chain reaction. We used logistic regression and considered a recessive model of inheritance for the analysis, with p < 0.05 for significance. RESULTS: A total of 836 women were assessed: 426 POP cases and 410 controls. The frequencies of CC, CT and TT genotypes were similar in both groups. Age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.07; 1.14), number of vaginal births (OR = 17.06, 95% CI = 5.94; 48.97), family history (OR = 2.87, 95% CI = 1.57; 5.22) and weight of largest newborn (OR = 1.001, 95% CI = 1.0003; 1.001) were independent risk factors for POP, while multiple cesarean sections (two or more) was protective (OR = 0.17, 95% CI = 0.07; 0.42). CONCLUSION: No association was detected between rs2165241 of the Loxl1 gene and POP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Posmenopausia / Prolapso de Órgano Pélvico Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Ethics Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Climacteric Asunto de la revista: GINECOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Posmenopausia / Prolapso de Órgano Pélvico Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Ethics Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Climacteric Asunto de la revista: GINECOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido