Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal-induced aversive behavior.
Neuropsychopharmacol Rep
; 42(2): 233-237, 2022 06.
Article
en En
| MEDLINE
| ID: mdl-35437943
AIM: Cessation of smoking induces nicotine withdrawal symptoms such as anxiety, depression, and dysphoria, which could lead to smoking relapse. In the present study, we examined the role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis (vBNST) on nicotine withdrawal-induced aversive behavior. METHODS: Nicotine dependence in rats was established by subcutaneous implantation with a nicotine-filled osmotic minipump on day 1. Nicotine withdrawal was precipitated by administration of the nicotine receptor antagonist, mecamylamine (3.0 mg/kg, s.c.), on day 15. Nicotine withdrawal-induced intra-vBNST noradrenaline release and aversive behavior were examined by in vivo microdialysis and a conditioned place aversion (CPA) test, respectively. RESULTS: Intra-vBNST noradrenaline release was significantly increased during nicotine withdrawal. Nicotine withdrawal induced aversive behavior, which was attenuated by intra-vBNST injection of the ß-adrenoceptor antagonist, timolol. CONCLUSIONS: These results suggest that enhanced noradrenergic transmission via ß-adrenoceptors in the vBNST plays a crucial role in nicotine withdrawal-induced aversive behavior.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Núcleos Septales
/
Síndrome de Abstinencia a Sustancias
Límite:
Animals
Idioma:
En
Revista:
Neuropsychopharmacol Rep
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos