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Helicobacter pylori Modulated Host Immunity in Gastric Cancer Patients With S-1 Adjuvant Chemotherapy.
Koizumi, Yuka; Ahmad, Sheny; Ikeda, Miyuki; Yashima-Abo, Akiko; Espina, Ginny; Sugimoto, Ryo; Sugai, Tamotsu; Iwaya, Takeshi; Tamura, Gen; Koeda, Keisuke; Liotta, Lance A; Takahashi, Fumiaki; Nishizuka, Satoshi S.
Afiliación
  • Koizumi Y; Division of Biomedical Research and Development, Iwate Medical University Institute for Biomedical Sciences, Yahaba, Japan.
  • Ahmad S; Aspiring Scientists Summer Internship Program, George Mason University, Manassas, VA, USA.
  • Ikeda M; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.
  • Yashima-Abo A; Division of Biomedical Research and Development, Iwate Medical University Institute for Biomedical Sciences, Yahaba, Japan.
  • Espina G; Division of Biomedical Research and Development, Iwate Medical University Institute for Biomedical Sciences, Yahaba, Japan.
  • Sugimoto R; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.
  • Sugai T; Department of Molecular Diagnostic Pathology, Iwate Medical University School of Medicine, Yahaba, Japan.
  • Iwaya T; Department of Molecular Diagnostic Pathology, Iwate Medical University School of Medicine, Yahaba, Japan.
  • Tamura G; Molecular Therapeutics Laboratory, Department of Surgery, Iwate Medical University School of Medicine, Yahaba, Japan.
  • Koeda K; Department of Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan.
  • Liotta LA; Department of Medical Safety Science, Iwate Medical University School of Medicine, Yahaba, Japan.
  • Takahashi F; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.
  • Nishizuka SS; Division of Medical Engineering, Department of Information Science, Iwate Medical University, Yahaba, Japan.
J Natl Cancer Inst ; 114(8): 1149-1158, 2022 08 08.
Article en En | MEDLINE | ID: mdl-35437596
BACKGROUND: Paradoxically, Helicobacter pylori-positive (HP+) advanced gastric cancer patients have a better prognosis than those who are HP-negative (HP-). Immunologic and statistical analyses can be used to verify whether systemic mechanisms modulated by HP are involved in this more favorable outcome. METHODS: A total of 658 advanced gastric cancer patients who underwent gastrectomy were enrolled. HP infection, mismatch repair, programmed death-ligand 1 (PD-L1) and CD4/CD8 proteins, and microsatellite instability were analyzed. Overall survival (OS) and relapse-free survival (RFS) rates were analyzed after stratifying clinicopathological factors. Cox proportional hazards regression analysis was performed to identify independent prognostic factors. RESULTS: Among 491 patients that were analyzed, 175 (36%) and 316 (64%) patients were HP+ and HP-, respectively. Analysis of RFS indicated an interaction of HP status among the subgroups for S-1 dose (Pinteraction = .049) and PD-L1 (P = .02). HP+ patients in the PD-L1- group had statistically higher 5-year OS and RFS than HP- patients (81% vs 68%; P = .0011; hazard ratio [HR] = 0.48, 95% confidence interval [CI] = 0.303 to 0.751, and 76% vs 63%; P = .001; HR = 0.508, 95% CI = 0.335 to 0.771, respectively). The 5-year OS and RFS was also statistically higher for HP+ compared with HP- patients in the "PD-L1- and S-1-r educed" group (86% vs 46%; P = .001; HR = 0.205, 95% CI = 0.07 to 0.602, and 83% vs 34%; P = .001; HR = 0.190, 95% CI = 0.072 to 0.498, respectively). Thus, HP status was identified as one of the most potentially important independent factors to predict prolonged survival. CONCLUSION: This retrospective study suggests that an HP-modulated host immune system may contribute to prolonged survival in the absence of immune escape mechanisms of gastric cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Helicobacter pylori Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Natl Cancer Inst Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Helicobacter pylori Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Natl Cancer Inst Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos