Your browser doesn't support javascript.
loading
Yin Yang 1-stimulated long noncoding RNA bladder cancer-associated transcript 1 upregulation facilitates esophageal carcinoma progression via the microRNA-5590-3p/programmed cell death-ligand 1 pathway.
Cheng, Jingge; Yang, Qian; Han, Xia; Wang, Haotian; Wu, Kun; Zhao, Hongye.
Afiliación
  • Cheng J; Thoracic Surgery Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  • Yang Q; Thoracic Surgery Department, Handan Central Hospital, Handan, China.
  • Han X; Thoracic Surgery Department, Xingtai People's Hospital, Xingtai, China.
  • Wang H; General Surgery Department, Xi'an Aerospace General Hospital, Xi'an, China.
  • Wu K; Anesthesiology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  • Zhao H; Dermatology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Bioengineered ; 13(4): 10244-10257, 2022 04.
Article en En | MEDLINE | ID: mdl-35435118
Esophageal carcinoma (EC) is a common gastrointestinal malignancy that poses a threat to public health worldwide. Long noncoding RNA (lncRNA) bladder cancer-associated transcript 1 (BLACAT1) exerts a tumorigenic role in several malignant tumors; nevertheless, its function in EC remains largely unknown. Besides, programmed cell death-ligand 1 (PD-L1), an oncogene in numerous human cancers, has been identified as a therapeutic target for EC. Therefore, we intended to explore the potential regulatory network involving BLACAT1 and PD-L1 in EC. In this study, we observed increased BLACAT1 and PD-L1 levels in EC tissues and EC cell lines. Moreover, YY1 could activate BLACAT1 transcription in EC cells (TE-1 and EC9706). In addition, in vitro and in vivo experiments demonstrated that BLACAT1 facilitated EC cell proliferation and metastasis and EC tumor growth. Also, the effects of BLACAT1 silencing on EC cell functions were partially reversed by PD-L1 overexpression. Besides, it was identified that BLACAT1 competed with PD-L1 to bind to miR-5590-3p in EC cells. Furthermore, miR-5590-3p suppression could abrogate the functional effects of BLACAT1 knockdown on EC cells; while PD-L1 silencing partly abolished the promoting effects of miR-5590-3p suppression on the biological functions of EC cells. To sum up, YY1-induced BLACAT1 accelerated EC progression via regulating the miR-5590-3p/PD-L1 axis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma / MicroARNs / ARN Largo no Codificante Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Bioengineered Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma / MicroARNs / ARN Largo no Codificante Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Bioengineered Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos