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Magnetic Resonance Imaging Assessment of Abdominal Ectopic Fat Deposition in Correlation With Cardiometabolic Risk Factors.
Zhang, Qin-He; Xie, Lu-Han; Zhang, Hao-Nan; Liu, Jing-Hong; Zhao, Ying; Chen, Li-Hua; Ju, Ye; Chen, An-Liang; Wang, Nan; Song, Qing-Wei; Xie, Li-Zhi; Liu, Ai-Lian.
Afiliación
  • Zhang QH; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Xie LH; Department of Pathology and Forensics, Dalian Medical University, Dalian, China.
  • Zhang HN; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Liu JH; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Zhao Y; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Chen LH; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Ju Y; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Chen AL; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Wang N; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Song QW; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Xie LZ; MR Research, GE Healthcare, Beijing, China.
  • Liu AL; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Front Endocrinol (Lausanne) ; 13: 820023, 2022.
Article en En | MEDLINE | ID: mdl-35432188
Purpose: Ectopic fat accumulation and abdominal fat distribution may have different cardiometabolic risk profiles. This study aimed to assess the associations between various magnetic resonance imaging (MRI)-acquired fat depots and cardiometabolic risk factors. Methods: A total of 320 subjects with median age of 59 years, 148 men and 172 women, were enrolled in the study. Visceral adipose tissue (VAT) area and fat fraction (FF), subcutaneous adipose tissue (SAT) area and FF at the L1-L2 levels, preperitoneal adipose tissue (pPAT) area and FF, hepatic FF, pancreatic FF, and intramuscular FF were assessed by MRI FF maps. The associations of various MRI-acquired fat depots with blood pressure, glucose, and lipid were examined using sex-stratified linear regression. Logistic regression stratified by sex was used to analyze the association of various MRI-acquired fat depots with the risk of hypertension, T2DM, and dyslipidemia. Results: The intraclass correlation coefficient (ICC) values were >0.9, which suggested good interobserver and intraobserver agreement. VAT area, V/S, hepatic fat, pancreatic fat, and pPAT rather than SAT area were significantly associated with multiple cardiometabolic risk factors (all p < 0.05). However, the patterns of these correlations varied by sex and specific risk factors. Also, VAT and SAT FF were only significantly associated with multiple cardiometabolic risk factors in women (all p < 0.05). Conclusions: VAT, hepatic fat, pancreatic fat, and pPAT were associated with cardiovascular metabolic risk factors independent of BMI. The patterns of these correlations were related to gender. These findings further the understanding of the association between ectopic fat deposition and cardiometabolic risk factors and help to better understand the obesity heterogeneity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Grasa Intraabdominal / Factores de Riesgo Cardiometabólico Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Grasa Intraabdominal / Factores de Riesgo Cardiometabólico Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza