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The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway.
Pan, You-Lu; Gong, Xiao-Meng; Hao, Rong-Rong; Zeng, Shen-Xin; Shen, Zheng-Rong; Huang, Wen-Hai.
Afiliación
  • Pan YL; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College Hangzhou Zhejiang China.
  • Gong XM; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College Hangzhou Zhejiang China.
  • Hao RR; Hangzhou Chinese Academy of Sciences, Hangzhou Medical College, Advanced Medical Technology Institute Hangzhou Zhejiang China.
  • Zeng SX; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College Hangzhou Zhejiang China.
  • Shen ZR; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College Hangzhou Zhejiang China.
  • Huang WH; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College Hangzhou Zhejiang China.
RSC Adv ; 12(16): 9763-9772, 2022 Mar 25.
Article en En | MEDLINE | ID: mdl-35424925
A facile CuBr2 induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields. In particular, some compounds exhibit bioactivity against cancer cell lines. This protocol shows advantages of low-cost, base-free, simple operation, and broad functional group tolerance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido