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Copper(ii) complexes with terpene derivatives of ethylenediamine: synthesis, and antibacterial, antifungal and antioxidant activity.
Gur'eva, Yana A; Zalevskaya, Olga A; Shevchenko, Oksana G; Slepukhin, Pavel A; Makarov, Vadim A; Kuchin, Aleksandr V.
Afiliación
  • Gur'eva YA; Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences 48, Pervomayskaya St. Syktyvkar 167000 Komi Republic Russian Federation zalevskayaoa@rambler.ru.
  • Zalevskaya OA; Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences 48, Pervomayskaya St. Syktyvkar 167000 Komi Republic Russian Federation zalevskayaoa@rambler.ru.
  • Shevchenko OG; Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences 28, Kommunisticheskaya St. Syktyvkar 167982 Komi Republic Russian Federation.
  • Slepukhin PA; I.Ya. Postovskii Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences 22/20, S. Kovalevskoy St. Ekaterinburg 620108 Russian Federation.
  • Makarov VA; Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences 33-2, Leninsky Prospekt Moscow 119071 Russian Federation.
  • Kuchin AV; Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences 48, Pervomayskaya St. Syktyvkar 167000 Komi Republic Russian Federation zalevskayaoa@rambler.ru.
RSC Adv ; 12(15): 8841-8851, 2022 Mar 21.
Article en En | MEDLINE | ID: mdl-35424859
The synthesis of new chiral copper(ii) complexes with terpene derivatives of ethylenediamine and the results of studying their antibacterial, antifungal and antioxidant activity in vitro are discussed. All studied copper complexes (1-4) showed significantly higher antifungal activity against the strains of C. albicans, S. salmonicolor and P. notatum compared to the activity of the clinical antifungal drug amphotericin. High antibacterial activity of copper complexes with terpene derivatives of ethylenediamine was revealed against the S. aureus (MRSA) strain, which is resistant to the reference antibiotic ciprofloxacin. Using various test systems, a comparative assessment of the antioxidant activity (AOA) of the synthesized copper complexes and the ligands was carried out. The salen-type complex 4, which has the highest AOA in the model of initiated oxidation of a substrate containing animal lipids, was superior to other copper complexes in the ability to protect erythrocytes under conditions of H2O2-induced hemolysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido