Your browser doesn't support javascript.
loading
Levamisole causes a transient increase in plasma creatinine levels but does not affect kidney function based on cystatin C.
Veltkamp, Floor; Bökenkamp, Arend; Slaats, Jeroen; Hamer, Henrike; Bouts, Antonia H M.
Afiliación
  • Veltkamp F; Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1109 AZ, Amsterdam, The Netherlands.
  • Bökenkamp A; Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1109 AZ, Amsterdam, The Netherlands.
  • Slaats J; Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, Free University, Amsterdam, The Netherlands.
  • Hamer H; Department of Clinical Chemistry, Amsterdam University Medical Centers, Free University, Amsterdam, The Netherlands.
  • Bouts AHM; Department of Clinical Chemistry, Amsterdam University Medical Centers, Free University, Amsterdam, The Netherlands.
Pediatr Nephrol ; 37(10): 2515-2519, 2022 10.
Article en En | MEDLINE | ID: mdl-35416496
BACKGROUND: In pediatric patients treated with levamisole to prevent relapses of idiopathic nephrotic syndrome (INS), a transient and non-progressive rise in creatinine levels has been observed. It has been suggested that levamisole affects tubular secretion of creatinine. However, other potential mechanisms - nephrotoxicity and interference with the analytical assay for creatinine - have never been thoroughly investigated. METHODS: In three steroid-sensitive nephrotic syndrome (SSNS) patients with elevated plasma creatinine levels, treated with levamisole 2.5 mg/kg every other day, serum cystatin C was determined. The glomerular filtration rate (GFR) was estimated using the full age spectrum for creatinine and the full age spectrum for cystatin C equations. Interference of levamisole with the enzymatic creatinine assay was tested using spare human plasma of different creatinine concentrations spiked with levamisole (4, 20, and 100 µM). RESULTS: Three patients who received levamisole with elevated plasma creatinine levels had normal serum cystatin C levels and corresponding estimated GFR. There was no assay interference. CONCLUSION: Levamisole increases plasma creatinine levels, which is most probably due to impaired tubular secretion of creatinine since there was no assay interference and patients had normal eGFR based on serum cystatin C. However, interference of metabolites of levamisole could not be excluded. To monitor GFR, cystatin C in addition to creatinine should be used and be measured before and during levamisole use.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Renales / Síndrome Nefrótico Tipo de estudio: Etiology_studies Límite: Child / Humans Idioma: En Revista: Pediatr Nephrol Asunto de la revista: NEFROLOGIA / PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Renales / Síndrome Nefrótico Tipo de estudio: Etiology_studies Límite: Child / Humans Idioma: En Revista: Pediatr Nephrol Asunto de la revista: NEFROLOGIA / PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania