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Associations between coronary/aortic 18F-sodium fluoride uptake and pro-atherosclerosis factors in patients with multivessel coronary artery disease.
Wen, Wanwan; Gao, Mingxin; Yun, Mingkai; Meng, Jingjing; Zhu, Ziwei; Yu, Wenyuan; Hacker, Marcus; Yu, Yang; Zhang, Xiaoli; Li, Xiang.
Afiliación
  • Wen W; Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Gao M; Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Yun M; Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Meng J; Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Zhu Z; Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Yu W; Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Hacker M; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
  • Yu Y; Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Zhang X; Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. xlzhang68@126.com.
  • Li X; Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
J Nucl Cardiol ; 29(6): 3352-3365, 2022 12.
Article en En | MEDLINE | ID: mdl-35415825
BACKGROUND: 18F-NaF PET/CT is a novel approach to detect and quantify microcalcification in atherosclerosis. We aimed to explore the underlying systematic vascular osteogenesis in the coronary artery and aorta in patients with multivessel coronary artery disease (CAD). METHODS: Patients with multivessel CAD prospectively underwent 18F-NaF PET/CT. The coronary microcalcification activity (CMA) and aortic microcalcification activity (AMA) were calculated based on both the volume and intensity of 18F-NaF PET activity. Peri-coronary adipose tissue (PCAT) density was measured in adipose tissue surrounding the coronary arteries and the 18F-NaF tissue-to-blood ratio (TBR) was measured in the coronary arteries. RESULTS: 100 patients with multivessel CAD were prospectively recruited. The CMA was significantly associated with the AMA (r = 0.70; P < .001). After multivariable adjustment, the CMA was associated with the AMA (Beta = 0.445 per SD increase; P < .001). The coronary TBR was also significantly associated with the PCAT density (r = 0.56; P < .001). The PCAT density was independently associated with the coronary TBR after adjusting confounding factors. CONCLUSIONS: Coronary 18F-NaF uptake was significantly associated with the PCAT density. There was a significant relationship between the coronary and the aortic 18F-NaF uptake. It might indicate an underlying systematic vascular osteogenesis in patients with multivessel CAD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Calcinosis / Aterosclerosis Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Calcinosis / Aterosclerosis Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos