Your browser doesn't support javascript.
loading
Heavy Atom-Free, Mitochondria-Targeted, and Activatable Photosensitizers for Photodynamic Therapy with Real-Time In-Situ Therapeutic Monitoring.
Miao, Junfeng; Huo, Yingying; Yao, Guangxiao; Feng, Yu; Weng, Jiajin; Zhao, Wei; Guo, Wei.
Afiliación
  • Miao J; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
  • Huo Y; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
  • Yao G; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
  • Feng Y; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
  • Weng J; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
  • Zhao W; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
  • Guo W; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
Angew Chem Int Ed Engl ; 61(25): e202201815, 2022 06 20.
Article en En | MEDLINE | ID: mdl-35412694
Based on spin-orbit charge transfer intersystem crossing mechanism, two heavy-atom-free photosensitizers (PSs) BDP1/BDP2 with absorption maxima at 506 nm/660 nm were constructed for photodynamic therapy (PDT). The long triplet state lifetimes and large singlet oxygen quantum yields, coupled with the mitochondria-targeted feature, made them highly phototoxic toward cancer cells. Moreover, the PDT-promoted cell apoptosis could be monitored by an obvious fluorescence off-on response of the two PSs due to the concomitant activation of extensive mitophagy, thus facilitating timely therapeutic feedback to avoid under- or over-treatment. Importantly, such design allows the activatable PSs Glu-BDP1/Glu-BDP2 to be fabricated by attaching γ-glutamyl, a substrate of γ-glutamyltranspeptidase, to the alkoxyaniline unit of BDP1/BDP2, and their ability in either selectively killing cancer cells over normal cells or in ablating implanted tumour without damage to healthy tissue was demonstrated.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Fármacos Fotosensibilizantes Idioma: En Revista: Angew Chem Int Ed Engl Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Fármacos Fotosensibilizantes Idioma: En Revista: Angew Chem Int Ed Engl Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania