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Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer.
Fankhauser, Christian D; de Vries, Hielke M; Roussel, Eduard; Jakobsen, Jakob Kristian; Issa, Allaudin; Lee, Esther W C; Schifano, Nicolo; Alnajjar, Hussain; Castiglione, Fabio; Antonelli, Luca; Oliveira, Pedro; Lau, Maurice; Parnham, Arie; Albersen, Maarten; Watkin, Nicholas A; Muneer, Asif; Ayres, Ben E; Brouwer, Oscar R; Sangar, Vijay.
Afiliación
  • Fankhauser CD; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK. cdfankhauser@gmail.com.
  • de Vries HM; Department of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland. cdfankhauser@gmail.com.
  • Roussel E; University of Zurich, Zurich, Switzerland. cdfankhauser@gmail.com.
  • Jakobsen JK; Luzerner Kantonsspital, Luzern, Switzerland. cdfankhauser@gmail.com.
  • Issa A; Department of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
  • Lee EWC; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Schifano N; Department of Urology, University Hospitals Leuven, Leuven, Belgium.
  • Alnajjar H; Department of Urology, Aarhus University Hospital, Aarhus, Denmark.
  • Castiglione F; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK.
  • Antonelli L; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK.
  • Oliveira P; NIHR Biomedical Research Centre, University College London Hospital, London, UK.
  • Lau M; Department of Urology, University College London Hospital, London, UK.
  • Parnham A; Division of Surgery and Interventional Science, UCL, London, UK.
  • Albersen M; NIHR Biomedical Research Centre, University College London Hospital, London, UK.
  • Watkin NA; Department of Urology, University College London Hospital, London, UK.
  • Muneer A; Division of Surgery and Interventional Science, UCL, London, UK.
  • Ayres BE; NIHR Biomedical Research Centre, University College London Hospital, London, UK.
  • Brouwer OR; Department of Urology, University College London Hospital, London, UK.
  • Sangar V; Division of Surgery and Interventional Science, UCL, London, UK.
J Cancer Res Clin Oncol ; 148(9): 2231-2234, 2022 Sep.
Article en En | MEDLINE | ID: mdl-35411405
PURPOSE: To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size. METHODS: Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurrence during follow-up at six European institutional high-volume centres was performed. ILN involvement was defined as cancer detected during ultrasound-guided fine-needle aspiration cytology, core needle biopsy, dynamic sentinel lymph node biopsy, ILN dissection or inguinal recurrence during follow-up. Uni- and multivariable logistic regression analyses were performed. RESULTS: In the cohort of 554 men with T1G2 penile cancer, from 6 European institutions, ILN metastases were observed in 46/554 men (8%, 95% confidence interval (CI) 6-11%). Men with both, LVI- and PNI- primary cancers had the lowest risk of ILN involvement (6%) whereas men with LVI + or PNI + showed ILN metastases in 22% and 30%. In multivariable regression, men with LVI + or PNI + had higher odds for ILN metastases compared to men with LVI- and PNI- (OR 3.9, 95% CI 1.6-9.0, p value < 0.01) Tumour size was not associated with ILN risk (OR 1.01 95% CI 0.99-1.04, p = 0.17). CONCLUSION: Approximately, one out of ten men with T1G2 overall and one out of four men with either LVI + or PNI + still have ILN metastases despite being clinically node negative. Therefore, invasive ILN staging should strongly be recommended in T1G2 with LVI + or PNI + but importantly, must be discussed in patients with T1G2 with LVI- or PNI-.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Pene Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: J Cancer Res Clin Oncol Año: 2022 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Pene Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: J Cancer Res Clin Oncol Año: 2022 Tipo del documento: Article Pais de publicación: Alemania