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In Vitro and In Vivo Effects of the Urokinase Plasminogen Activator Inhibitor WX-340 on Anaplastic Thyroid Cancer Cell Lines.
Baldini, Enke; Presutti, Dario; Favoriti, Pasqualino; Santini, Simonetta; Papoff, Giuliana; Tuccilli, Chiara; Carletti, Raffaella; Di Gioia, Cira; Lori, Eleonora; Ferent, Iulia Catalina; Gagliardi, Federica; Catania, Antonio; Pironi, Daniele; Tripodi, Domenico; D'Andrea, Vito; Sorrenti, Salvatore; Ruberti, Giovina; Ulisse, Salvatore.
Afiliación
  • Baldini E; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Presutti D; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo, 00015 Rome, Italy.
  • Favoriti P; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Santini S; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo, 00015 Rome, Italy.
  • Papoff G; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo, 00015 Rome, Italy.
  • Tuccilli C; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Carletti R; Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Di Gioia C; Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Lori E; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Ferent IC; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Gagliardi F; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Catania A; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Pironi D; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Tripodi D; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • D'Andrea V; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Sorrenti S; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Ruberti G; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Monterotondo, 00015 Rome, Italy.
  • Ulisse S; Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Int J Mol Sci ; 23(7)2022 Mar 28.
Article en En | MEDLINE | ID: mdl-35409084
Increased expression of the urokinase-type plasminogen activator (uPA) system is associated with tumor invasion, neo-angiogenesis, and metastatic spread, and has been shown to positively correlate with a poor prognosis in several cancer types, including thyroid carcinomas. In recent years, several uPA inhibitors were found to have anticancer effects in preclinical studies and in some phase II clinical trials, which prompted us to evaluate uPA as a potential therapeutic target for the treatment of patients affected by the most aggressive form of thyroid cancer, the anaplastic thyroid carcinoma (ATC). In this study, we evaluated the in vitro and in vivo effects of WX-340, a highly specific and selective uPA inhibitor, on two ATC-derived cell lines, CAL-62 and BHT-101. The results obtained indicated that WX-340 was able to reduce cell adhesion and invasiveness in a dose-dependent manner in both cell lines. In addition, WX-340 increased uPA receptor (uPAR) protein levels without affecting its plasma membrane concentration. However, this compound was unable to significantly reduce ATC growth in a xenograft model, indicating that uPA inhibition alone may not have the expected therapeutic effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Carcinoma Anaplásico de Tiroides Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Carcinoma Anaplásico de Tiroides Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza