Evidence for the involvement of cerebral renin-angiotensin system (RAS) in stress analgesia.
Pain
; 27(2): 237-245, 1986 Nov.
Article
en En
| MEDLINE
| ID: mdl-3540814
Studies concerning variations of the central renin-angiotensin system (RAS) during immobilization stress in rats have shown a significant increase in renin-like activity in the hypothalamus and fronto-parietal cortex, together with a definite decrease in the hypophysis and pineal gland. The resultant stress analgesia is blocked by the previous administration of naloxone and saralasin (angiotensin II antagonist). The intracerebral administration of renin and angiotensin II produces an increase in latencies to thermoalgesic stimuli; this is reduced, as is immobilization stress, by naloxone and saralasin. Both chemical hypophysectomy obtained by dexamethasone pretreatment as well as surgical epiphysectomy block the stress-induced analgesia. The experimental data obtained argue in favour of the participation of the cerebral RAS in stress analgesia through the indirect mechanism of release of opioid peptides.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Renina-Angiotensina
/
Estrés Fisiológico
/
Encéfalo
/
Analgesia
Límite:
Animals
Idioma:
En
Revista:
Pain
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos