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Analysis of Faecal Microbiota and Small ncRNAs in Autism: Detection of miRNAs and piRNAs with Possible Implications in Host-Gut Microbiota Cross-Talk.
Chiappori, Federica; Cupaioli, Francesca Anna; Consiglio, Arianna; Di Nanni, Noemi; Mosca, Ettore; Licciulli, Vito Flavio; Mezzelani, Alessandra.
Afiliación
  • Chiappori F; Institute for Biomedical Technologies, National Research Council of Italy, 20054 Segrate, Italy.
  • Cupaioli FA; Institute for Biomedical Technologies, National Research Council of Italy, 20054 Segrate, Italy.
  • Consiglio A; Institute for Biomedical Technologies, National Research Council of Italy, 70126 Bari, Italy.
  • Di Nanni N; Institute for Biomedical Technologies, National Research Council of Italy, 20054 Segrate, Italy.
  • Mosca E; Institute for Biomedical Technologies, National Research Council of Italy, 20054 Segrate, Italy.
  • Licciulli VF; Institute for Biomedical Technologies, National Research Council of Italy, 70126 Bari, Italy.
  • Mezzelani A; Institute for Biomedical Technologies, National Research Council of Italy, 20054 Segrate, Italy.
Nutrients ; 14(7)2022 Mar 23.
Article en En | MEDLINE | ID: mdl-35405953
Intestinal microorganisms impact health by maintaining gut homeostasis and shaping the host immunity, while gut dysbiosis associates with many conditions, including autism, a complex neurodevelopmental disorder with multifactorial aetiology. In autism, gut dysbiosis correlates with symptom severity and is characterised by a reduced bacterial variability and a diminished beneficial commensal relationship. Microbiota can influence the expression of host microRNAs that, in turn, regulate the growth of intestinal bacteria by means of bidirectional host-gut microbiota cross-talk. We investigated possible interactions among intestinal microbes and between them and host transcriptional modulators in autism. To this purpose, we analysed, by "omics" technologies, faecal microbiome, mycobiome, and small non-coding-RNAs (particularly miRNAs and piRNAs) of children with autism and neurotypical development. Patients displayed gut dysbiosis related to a reduction of healthy gut micro- and mycobiota as well as up-regulated transcriptional modulators. The targets of dysregulated non-coding-RNAs are involved in intestinal permeability, inflammation, and autism. Furthermore, microbial families, underrepresented in patients, participate in the production of human essential metabolites negatively influencing the health condition. Here, we propose a novel approach to analyse faeces as a whole, and for the first time, we detected miRNAs and piRNAs in faecal samples of patients with autism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / MicroARNs / Microbiota / Microbioma Gastrointestinal Tipo de estudio: Diagnostic_studies Límite: Child / Humans Idioma: En Revista: Nutrients Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / MicroARNs / Microbiota / Microbioma Gastrointestinal Tipo de estudio: Diagnostic_studies Límite: Child / Humans Idioma: En Revista: Nutrients Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza