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Role of the prorenin receptor in endometrial cancer cell growth.
Martin, Jacinta H; Mohammed, Riazuddin; Delforce, Sarah J; Skerrett-Byrne, David A; de Meaultsart, Celine Corbisier; Almazi, Juhura G; Stephens, Andrew N; Verrills, Nicole M; Dimitriadis, Evdokia; Wang, Yu; Lumbers, Eugenie R; Pringle, Kirsty G.
Afiliación
  • Martin JH; School of Biomedical Sciences and Pharmacy, Priority Research Centre for Reproductive Science, Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia.
  • Mohammed R; These authors contributed equally to this work.
  • Delforce SJ; School of Biomedical Sciences and Pharmacy, Priority Research Centre for Reproductive Science, Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia.
  • Skerrett-Byrne DA; These authors contributed equally to this work.
  • de Meaultsart CC; School of Biomedical Sciences and Pharmacy, Priority Research Centre for Reproductive Science, Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia.
  • Almazi JG; School of Environmental and Life Sciences, Priority Research Centre for Reproductive Science, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia.
  • Stephens AN; School of Biomedical Sciences and Pharmacy, Priority Research Centre for Reproductive Science, Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia.
  • Verrills NM; School of Biomedical Sciences and Pharmacy, Priority Research Centre for Cancer Research, Innovation and Translation, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia.
  • Dimitriadis E; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia.
  • Wang Y; Hudson Institute of Medical Research, Clayton, Victoria, Australia.
  • Lumbers ER; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia.
  • Pringle KG; School of Biomedical Sciences and Pharmacy, Priority Research Centre for Cancer Research, Innovation and Translation, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia.
Oncotarget ; 13: 587-599, 2022.
Article en En | MEDLINE | ID: mdl-35401936
Endometrial cancer is the most diagnosed gynecological malignancy. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer continues to rise. Emerging evidence suggests a putative role of the (pro)renin receptor ((P)RR), in the ontogenesis of endometrial cancer. The (P)RR is implicated in breast cancer and pancreatic carcinoma pathophysiology by virtue of its role in proliferation, angiogenesis, fibrosis, migration and invasion. Thus, we aimed to investigate the functional role of the (P)RR in human endometrial cancer. We employed an siRNA-mediated knockdown approach to abrogate (P)RR expression in the endometrial epithelial cell lines; Ishikawa, AN3CA and HEC-1-A and examined cellular proliferation and viability. We also carried out a sophisticated proteomic screen to explore potential pathways via which the (P)RR is acting in endometrial cancer physiology. These data confirmed that the (P)RR is critical for endometrial cancer development, contributing to both its proliferative capacity and in the maintenance of cell viability. This is likely mediated through proteins such as MGA, SLC4A7, SLC7A11 or DHRS2, which were reduced following (P)RR knockdown. These putative protein interactions/pathways, which rely on the presence of the (P)RR, are likely to contribute to endometrial cancer progression and could therefore, represent several novel therapeutic targets for endometrial cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Renina / Neoplasias Endometriales Límite: Female / Humans Idioma: En Revista: Oncotarget Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Renina / Neoplasias Endometriales Límite: Female / Humans Idioma: En Revista: Oncotarget Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos