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Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol.
Li, Xing-Zi; Jiang, Shi-You; Li, Guo-Qiang; Jiang, Qian-Ru; Li, Jue-Wan; Li, Chen-Chen; Han, Yu-Qin; Song, Bao-Liang; Ma, Xin-Ran; Qi, Wei; Qiu, Wen-Wei.
Afiliación
  • Li XZ; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
  • Jiang SY; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, 430072, Wuhan, China.
  • Li GQ; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
  • Jiang QR; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
  • Li JW; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Li CC; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
  • Han YQ; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, 430072, Wuhan, China.
  • Song BL; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, 430072, Wuhan, China.
  • Ma XR; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. Electronic address: xrma@bio.ecnu.edu.cn.
  • Qi W; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. Electronic address: qiwei@shanghaitech.edu.cn.
  • Qiu WW; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. Electronic address: wwqiu@chem.ecnu.edu.cn.
Eur J Med Chem ; 236: 114323, 2022 Jun 05.
Article en En | MEDLINE | ID: mdl-35397399
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Enfermedad del Hígado Graso no Alcohólico / Hidroximetilglutaril-CoA Reductasas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Enfermedad del Hígado Graso no Alcohólico / Hidroximetilglutaril-CoA Reductasas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia