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Emerging role of syndecans in maintaining homeostasis of colon epithelium during inflammation.
Hwang, Jisun; Park, Eunhye; Choi, Yeong-Woo; Min, Shinhye; Oh, Eok-Soo.
Afiliación
  • Hwang J; Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea.
  • Park E; Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea.
  • Choi YW; Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea.
  • Min S; Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea.
  • Oh ES; Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea.
Am J Physiol Cell Physiol ; 322(5): C960-C966, 2022 05 01.
Article en En | MEDLINE | ID: mdl-35385327
The syndecans are a family of transmembrane proteoglycans that are widespread in mammalian tissues. Located at the cell surface membrane, they contribute to modulating the composition of the extracellular matrix via glycosaminoglycan chains (GAGs) attached to their extracellular domains. Syndecans can interact with a variety of extracellular ligands through their core proteins and GAGs, and may also transmit signals through their transmembrane domain to regulate intracellular functions. These properties enable syndecan to modulate glycocalyx formation, epithelial cell-to-cell connections for cell barrier formation, and epithelial cell-lamina propria interactions in the colon epithelium, all of which are crucial for the homeostasis of this tissue. Inflammation induces structural alterations of the colon epithelium, and accumulating evidence suggests that syndecan expression might play important regulatory functions during inflammation. This review summarizes the possible roles of syndecans in maintaining tissue homeostasis in the colon epithelium, especially under inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colon / Inflamación Límite: Animals Idioma: En Revista: Am J Physiol Cell Physiol Asunto de la revista: FISIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colon / Inflamación Límite: Animals Idioma: En Revista: Am J Physiol Cell Physiol Asunto de la revista: FISIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos