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Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges.
Li, Shangyong; Zhang, Hui; Chen, Kaiwei; Jin, Mengfei; Vu, Son Hai; Jung, Samil; He, Ningning; Zheng, Zhou; Lee, Myeong-Sok.
Afiliación
  • Li S; School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
  • Zhang H; Molecular Cancer Biology Laboratory, Cellular Heterogeneity Research Center, Department of Biosystem, Sookmyung Women's University, Seoul, Korea.
  • Chen K; School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
  • Jin M; School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
  • Vu SH; School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
  • Jung S; Molecular Cancer Biology Laboratory, Cellular Heterogeneity Research Center, Department of Biosystem, Sookmyung Women's University, Seoul, Korea.
  • He N; Institute of Applied Sciences, Ho Chi Minh City University of Technology HUTECH, Ho Chi Minh City, Viet Nam.
  • Zheng Z; Molecular Cancer Biology Laboratory, Cellular Heterogeneity Research Center, Department of Biosystem, Sookmyung Women's University, Seoul, Korea.
  • Lee MS; School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
Drug Deliv ; 29(1): 1142-1149, 2022 Dec.
Article en En | MEDLINE | ID: mdl-35384787
Oral drug delivery systems (ODDSs) have various advantages of simple operation and few side effects. ODDSs are highly desirable for colon-targeted therapy (e.g. ulcerative colitis and colorectal cancer), as they improve therapeutic efficiency and reduce systemic toxicity. Chitosan/alginate nanoparticles (CANPs) show strong electrostatic interaction between the carboxyl group of alginates and the amino group of chitosan which leads to shrinkage and gel formation at low pH, thereby protecting the drugs from the gastrointestinal tract (GIT) and aggressive gastric environment. Meanwhile, CANPs as biocompatible polymer, show intestinal mucosal adhesion, which could extend the retention time of drugs on inflammatory sites. Recently, CANPs have attracted increasing interest as colon-targeted oral drug delivery system for intestinal diseases. The purpose of this review is to summarize the application and treatment of CANPs in intestinal diseases and insulin delivery. And then provide a future perspective of the potential and development direction of CANPs as colon-targeted ODDSs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Quitosano / Nanopartículas Límite: Humans Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Quitosano / Nanopartículas Límite: Humans Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido