Your browser doesn't support javascript.
loading
The Biological Basis for Surface-dependent Regulation of Osteogenesis and Implant Osseointegration.
Boyan, Barbara D; Berger, Michael B; Nelson, Fred R; Donahue, Henry J; Schwartz, Zvi.
Afiliación
  • Boyan BD; From the Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA (Boyan, Berger, Donahue, and Schwartz), the Wallace B. Coulter Department at Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA (Boyan), the Department of Orthopaedics, Henry Ford Hospital, School of Medicine, Wayne State University, Detroit, MI (Nelson), and the Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX (Schwartz).
J Am Acad Orthop Surg ; 30(13): e894-e898, 2022 07 01.
Article en En | MEDLINE | ID: mdl-35383608
Bone marrow stromal cells are regulated by the chemical and physical features of a biomaterial surface. When grown on titanium (Ti) and Ti alloy surfaces, such as titanium-aluminum-vanadium, with specific topographies that mimic the microscale, mesoscale, and nanoscale features of an osteoclast resorption pit, they undergo a rapid change in cell shape to assume a columnar morphology typical of a secretory osteoblast. These cells exhibit markers associated with an osteoblast phenotype, including osteocalcin and osteopontin, and they secrete factors associated with osteogenesis, including bone morphogenetic protein 2, vascular endothelial growth factor, and neurotrophic semaphorins. The pathway involves a shift in integrin expression from α5ß1 to α2ß1 and signaling by Wnt5a rather than Wnt3a. Conditioned media from these cultures can stimulate vasculogenesis by human endothelial cells and osteoblastic differentiation of marrow stromal cells not grown on the biomimetic substrate, suggesting that the surface could promote osteogenesis in vivo through similar mechanisms. In vivo studies using a variety of animal models confirm that implants with biomimetic surfaces result in improved osseointegration compared with Ti implants with smooth surfaces, as do meta-analyses comparing clinical performance of implant surface topographies.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / Oseointegración Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Am Acad Orthop Surg Asunto de la revista: ORTOPEDIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / Oseointegración Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Am Acad Orthop Surg Asunto de la revista: ORTOPEDIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos