Your browser doesn't support javascript.
loading
The longitudinal effects of chronotype on chemotherapy-induced nausea and vomiting in patients with breast cancer receiving neoadjuvant chemotherapy.
Jung, Sanghyup; Son, Kyung-Lak; Jung, Saim; Moon, Jung Yoon; Oh, Gyu Han; Yeom, Chan-Woo; Lee, Kwang-Min; Kim, Won-Hyoung; Jung, Dooyoung; Kim, Tae-Yong; Im, Seock-Ah; Lee, Kyung-Hun; Spiegel, David; Hahm, Bong-Jin.
Afiliación
  • Jung S; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
  • Son KL; Department of Psychiatry, Dongguk University Ilsan Hospital, Goyang, Republic of Korea. Electronic address: klson01@gmail.com.
  • Jung S; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
  • Moon JY; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
  • Oh GH; Public Health Medical Service, Seoul National University Hospital, Seoul, Republic of Korea.
  • Yeom CW; Department of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu-si, Gyeonggi-do, Republic of Korea.
  • Lee KM; Mind Lab the Place, Seoul, Republic of Korea.
  • Kim WH; Department of Psychiatry, Inha University Hospital, Incheon, Republic of Korea.
  • Jung D; Department of Human Factors Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
  • Kim TY; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.
  • Im SA; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.
  • Lee KH; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.
  • Spiegel D; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Hahm BJ; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
J Psychosom Res ; 157: 110804, 2022 06.
Article en En | MEDLINE | ID: mdl-35381494
OBJECTIVE: The object of this longitudinal cohort study was to investigate whether chronotype affects the incidence of chemotherapy-induced nausea and vomiting (CINV) among patients with breast cancer. METHODS: The study included a total of 203 breast cancer patients who received neoadjuvant chemotherapy using a regimen of doxorubicin and cyclophosphamide with high emetogenicity. Patients received four cycles of chemotherapy in approximately three months. Patients completed questionnaires including the Munich Chronotype Questionnaire (MCTQ) before the first chemotherapy and the Multinational Association of Supportive Care in Cancer Antiemesis Tool (MAT) after each of the four chemotherapy sessions. To confirm the effect of chronotype on CINV during the four cycles, we performed statistical analyses using a generalized estimating equation (GEE). RESULTS: CINV occurred in 108 (53.2%), 112 (55.2%), 102 (50.3%), and 62 (30.5%) patients during four cycles of treatment. In the GEE approach, late and early chronotypes (vs. intermediate chronotype) were associated with an increased risk of CINV (late chronotype: odds ratio [OR], 2.06; 95% confidence interval [CI], 1.41-2.99; p < 0.001, early chronotype: OR, 1.84; CI, 1.25-2.73; p = 0.002), which remained significant even after adjusting for age, BMI, antiemetic treatment, history of nausea and vomiting, anxiety, and sleep quality. CONCLUSION: Chronotype affected CINV across the four cycles of neoadjuvant chemotherapy in patients with breast cancer, suggesting the need to consider chronotype in predicting and managing CINV.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Neoplasias de la Mama / Antieméticos / Antineoplásicos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Psychosom Res Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Neoplasias de la Mama / Antieméticos / Antineoplásicos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Psychosom Res Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido