Unconventional Intestinal Intraepithelial Lymphocytes in Health and Disease.
Crit Rev Immunol
; 41(4): 23-38, 2021.
Article
en En
| MEDLINE
| ID: mdl-35381141
The intestinal epithelium is constantly exposed to a myriad of antigenic stimuli derived from commensals, food particles and pathogens present in the lumen of the intestines. This complex environment requires a similarly complex immune system capable of preventing exacerbated responses against food particles and commensals, while at the same time eliminating potential pathogens. These functions are accomplished in part by the intraepithelial lymphocyte (IEL) compartment. IELs are a diverse group of immune cells that primarily reside in between intestinal epithelial cells, maintaining an intimate association with these cells. IELs are a diverse population of cells: some of them express a T cell receptor (TCR), while others do not, and within TCR+ and TCR- IELs there are many IEL subpopulations that represent different developmental pathways and functions. In this review, we will focus on "unconventional" T cells present in the intestinal epithelium, in particular TCRγδ+, TCRαß+CD4+CD8αα+, and TCRαß+CD8αα+ IELs. We will discuss their development and potential functions both in humans and in mice.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos Intraepiteliales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Crit Rev Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos