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Intra-articular injection with platelet-rich plasma compared to triamcinolone hexacetonide or saline solution in knee osteoarthritis: A double blinded randomized controlled trial with one year follow-up.
Nunes-Tamashiro, José Carlos; Natour, Jamil; Ramuth, Fernando Maier; Toffolo, Sandra Regina; Mendes, Jamile Godoy; Rosenfeld, André; Furtado, Rita Nely Vilar.
Afiliación
  • Nunes-Tamashiro JC; Academic of Rheumatology Division, 58804from Universidade Federal de São Paulo- Escola Paulista de Medicina (Unifesp - EPM), Sao Paulo, Brazil.
  • Natour J; Professor of Rheumatology Division and Head of Ambulatory of Rheumatology Interventions, 28105from Universidade Federal de São Paul o- Escola Paulista de Medicina (Unifesp - EPM), Sao Paulo, Brazil.
  • Ramuth FM; Academic of Rheumatology Division, 58804from Universidade Federal de São Paulo- Escola Paulista de Medicina (Unifesp - EPM), Sao Paulo, Brazil.
  • Toffolo SR; Academic of Rheumatology Division, 58804from Universidade Federal de São Paulo- Escola Paulista de Medicina (Unifesp - EPM), Sao Paulo, Brazil.
  • Mendes JG; Academic of Rheumatology Division, 58804from Universidade Federal de São Paulo- Escola Paulista de Medicina (Unifesp - EPM), Sao Paulo, Brazil.
  • Rosenfeld A; Department of Diagnostic Imaging, 28105from Universidade Federal de São Paulo - Escola Paulista de Medicina (Unifesp - EPM), Sao Paulo, Brazil.
  • Furtado RNV; 28105Rheumatologist and Physiatrist Affiliated Professor from Universidade Federal de São Paulo - Escola Paulista de Medicina (Unifesp - EPM), Sao Paulo, Brazil.
Clin Rehabil ; 36(7): 900-915, 2022 Jul.
Article en En | MEDLINE | ID: mdl-35379019
OBJECTIVES: To compare the effectiveness of intra-articular injection (IAI) of Platelet-Rich Plasma (PRP) with Triamcinolone Hexacetonide (TH) and Saline Solution (SS), in patients with knee osteoarthritis (OA). DESIGN: A randomized controlled trial, with blinded patients and assessor. SETTING: Outpatient rheumatology service. SUBJECTS: Patients with knee osteoarthritis grades II and III. INTERVENTIONS: Patients received IAI with PRP, 40 mg TH, or SS. METHODS: Patients were assessed at baseline and after 4, 8, 12 e 52 weeks with: visual analogue scale (VAS) for pain at rest and movement, WOMAC questionnaire, Timed to Up and Go test, 6-min walk test, percentage of improvement, goniometry, quality of life SF-36 questionnaire, Likert scale and Kelgreen & Lawrence (KL) radiographic scale (only at baseline and 52 weeks). RESULTS: 100 patients were studied, with a mean age of 67.13(6.56) years. The TH group was superior for: percentage of improvement (versus SS group from 4 to 52 weeks); WOMAC total and pain (versus PRP group at 4 weeks); and WOMAC stiffness (versus SS group at 12 weeks). The SS group was inferior for WOMAC function (from 8 to 52 weeks). The PRP group showed lowest radiographic progression [TH 17 (51.51%) to 24 (72.72%); SS 17 (51.51%) to 30 (90.90%); PRP 20 (58.82%) to 21 (61.76%)]. CONCLUSION: The Triamcinolone Hexacetonide group was superior for percentage of improvement and WOMAC, pain and stiffness. For the WOMAC function, the Platelet-Rich Plasma group and Triamcinolone Hexacetonide group were superior to the Saline group. The Platelet-Rich Plasma group showed the lowest radiographic progression at 52 weeks of follow-up.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis de la Rodilla / Plasma Rico en Plaquetas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Aspecto: Patient_preference Límite: Aged / Humans Idioma: En Revista: Clin Rehabil Asunto de la revista: REABILITACAO Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis de la Rodilla / Plasma Rico en Plaquetas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Aspecto: Patient_preference Límite: Aged / Humans Idioma: En Revista: Clin Rehabil Asunto de la revista: REABILITACAO Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido