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Electroacupuncture at PC6 (Neiguan) Attenuates Angina Pectoris in Rats with Myocardial Ischemia-Reperfusion Injury Through Regulating the Alternative Splicing of the Major Inhibitory Neurotransmitter Receptor GABRG2.
Qi, Wenchuan; Fu, Hongjuan; Luo, Xinye; Ren, Yanrong; Liu, Xueying; Dai, Hongyuan; Zheng, Qianhua; Liang, Fanrong.
Afiliación
  • Qi W; Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
  • Fu H; Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
  • Luo X; Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
  • Ren Y; Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
  • Liu X; Shanxi University of Traditional Chinese Medicine, Jinzhong, 030002, Shanxi, China.
  • Dai H; Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
  • Zheng Q; Shanxi University of Traditional Chinese Medicine, Jinzhong, 030002, Shanxi, China.
  • Liang F; College of Life Sciences, Sichuan University, Chengdu, 610065, Sichuan, China.
J Cardiovasc Transl Res ; 15(5): 1176-1191, 2022 10.
Article en En | MEDLINE | ID: mdl-35377129
Angina pectoris is the most common manifestation of coronary heart disease, causing suffering in patients. Electroacupuncture at PC6 can effectively alleviate angina by regulating the expression of genes, whether the alternative splicing (AS) of genes is affected by acupuncture is still unknown. We established a rat model of myocardial ischemia-reperfusion by coronary artery ligation and confirmed electroacupuncture alleviated the abnormal discharge caused by angina pectoris measured in EMG electromyograms. Analysis of the GSE61840 dataset established that AS events were altered after I/R and regulated by electroacupuncture. I/R decreased the expression of splicing factor Nova1 while electroacupuncture rescued it. Further experiments in dorsal root ganglion cells showed Nova1 regulated the AS of the GABRG2, specifically on its exon 9 where an important phosphorylation site is present. In vivo, results also showed that electroacupuncture can restore AS of GABRG2. Our results proved that electroacupuncture alleviates angina results by regulating alternative splicing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Electroacupuntura / Isquemia Miocárdica Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Electroacupuntura / Isquemia Miocárdica Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos