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Characterizing and Evaluating Diurnal Salivary Uric Acid Across Pregnancy Among Healthy Women.
Riis, Jenna L; Cook, Stephanie H; Letourneau, Nicole; Campbell, Tavis; Granger, Douglas A; Giesbrecht, Gerald F.
Afiliación
  • Riis JL; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, United States.
  • Cook SH; Department of Psychological Science, School of Social Ecology, University of California, Irvine, Irvine, CA, United States.
  • Letourneau N; Social and Behavioral Sciences, School of Global Public Health, New York University, New York, NY, United States.
  • Campbell T; Biostatistics, School of Global Public Health, New York University, New York, NY, United States.
  • Granger DA; Alberta Children's Hospital Research Institute, Calgary, AB, Canada.
  • Giesbrecht GF; Department of Pediatrics, University of Calgary, Calgary, AB, Canada.
Front Endocrinol (Lausanne) ; 13: 813564, 2022.
Article en En | MEDLINE | ID: mdl-35370953
Uric acid levels during pregnancy have been examined as a potential indicator of risk for gestational diabetes mellites, hypertension, and related adverse birth outcomes. However, evidence supporting the utility of serum uric acid levels in predicting poor maternal and fetal health has been mixed. The lack of consistent findings may be due to limitations inherent in serum-based biomeasure evaluations, such as minimal repeated assessments and variability in the timing of these assessments. To address these gaps, we examined repeated measurements of diurnal salivary uric acid (sUA) levels in a sample of 44 healthy women across early-mid and late pregnancy. We assessed potential covariates and confounds of sUA levels and diurnal trajectories, as well as associations between maternal weight gain and blood pressure during pregnancy and sUA concentrations. Using multilevel linear models, we found sUA increased across pregnancy and displayed a robust diurnal pattern with the highest concentrations at waking, a steep decline in the early morning, and decreasing levels across the day. Maternal pre-pregnancy BMI, age, prior-night sleep duration, and fetal sex were associated with sUA levels and/or diurnal slopes. Maternal blood pressure and gestational weight gain also showed significant associations with sUA levels across pregnancy. Our results expand upon those found with serum UA measurements. Further, they demonstrate the feasibility of using at-home, minimally-invasive saliva sampling procedures to track UA levels across pregnancy with potential applications for the long-term monitoring of maternal cardiometabolic risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Diabetes Gestacional / Ganancia de Peso Gestacional Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Diabetes Gestacional / Ganancia de Peso Gestacional Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza