A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels.

Valdés-Jiménez, Alejandro; Jiménez-González, Daniel; Kiper, Aytug K; Rinné, Susanne; Decher, Niels; González, Wendy; Reyes-Parada, Miguel; Núñez-Vivanco, Gabriel

Valdés-Jiménez, Alejandro; Jiménez-González, Daniel; Kiper, Aytug K; Rinné, Susanne; Decher, Niels; González, Wendy; Reyes-Parada, Miguel; Núñez-Vivanco, Gabriel.

Afiliación

Valdés-Jiménez A; Center for Bioinformatics, Simulations and Modelling, Faculty of Engineering, University of Talca, Talca, Chile.
Jiménez-González D; Computer Architecture Department, Universitat Politécnica de Catalunya, Barcelona, Spain.
Kiper AK; Computer Architecture Department, Universitat Politécnica de Catalunya, Barcelona, Spain.
Rinné S; Barcelona Supercomputing Center, Barcelona, Spain.
Decher N; Institute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.
González W; Institute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.
Reyes-Parada M; Institute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.
Núñez-Vivanco G; Center for Bioinformatics, Simulations and Modelling, Faculty of Engineering, University of Talca, Talca, Chile.

Front Pharmacol ; 13: 855792, 2022.

Article en En | MEDLINE | ID: mdl-35370665

Palabras clave

binding site comparisons; binding site similarity; cardiac ion channels; polypharmacology; tafluprost

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Suiza

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