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Perfluorinated alkyl substances in Canadian human milk as part of the Maternal-Infant Research on Environmental Chemicals (MIREC) study.
Rawn, Dorothea F K; Dufresne, Guy; Clément, Geneviève; Fraser, William D; Arbuckle, Tye E.
Afiliación
  • Rawn DFK; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada. Electronic address: thea.rawn@hc-sc.gc.ca.
  • Dufresne G; Health Canada, Health Products Laboratory Program, Health Products Laboratory and Microbiology Laboratory Longueuil, 1001 Saint-Laurent Ouest, Longueuil, QC J4K 1C7, Canada.
  • Clément G; Health Canada, Health Products Laboratory Program, Health Products Laboratory and Microbiology Laboratory Longueuil, 1001 Saint-Laurent Ouest, Longueuil, QC J4K 1C7, Canada.
  • Fraser WD; CHU Sainte-Justine, Centre de recherche, Université de Montréal, Montréal, QC, Canada. Current Address: Centre hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
  • Arbuckle TE; Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Address Locator: 0801A, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
Sci Total Environ ; 831: 154888, 2022 Jul 20.
Article en En | MEDLINE | ID: mdl-35367260
Perfluorinated alkyl substances (PFAS) were determined in human milk samples (n = 664) from participants in the Maternal-Infant Research on Environmental Chemicals (MIREC) study. ΣPFAS concentrations (sum of seven PFAS) ranged from 3.1 ng L-1 to 603 ng L-1, with a median concentration of 106 ng L-1 in the Canadian mothers' milk analyzed. These data comprise the first pan-Canadian dataset of PFAS in human milk. Perfluorooctanoic acid (PFOA) and linear perfluorooctanesulfonate (L-PFOS) were the dominant contributors to ΣPFAS in human milk samples. An inverse relationship between ΣPFAS concentrations and age was observed (Spearman correlation - 0.184). Primiparous women had elevated PFAS concentrations in milk relative to women who had children previously (p < 0.001). In contrast, the region of maternal birth did not influence ΣPFAS concentrations (p = 0.156). Although China and Norway have observed consistently detectable levels of perfluoroundecanoic acid (PFUdA) in human milk, PFAS with long carbon chains (n ≥ 11) were not present above method detection limits in Canadian human milk samples analyzed as part of the MIREC study. In conclusion, despite the presence of low levels of environmental contaminants in human milk, Health Canada supports breastfeeding due to the benefits to both infants and mothers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Alcanesulfónicos / Contaminantes Ambientales / Fluorocarburos Límite: Child / Female / Humans / Infant País/Región como asunto: America do norte / Asia Idioma: En Revista: Sci Total Environ Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Alcanesulfónicos / Contaminantes Ambientales / Fluorocarburos Límite: Child / Female / Humans / Infant País/Región como asunto: America do norte / Asia Idioma: En Revista: Sci Total Environ Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos