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Glycoprotein NMB promotes tumor formation and malignant progression of laryngeal squamous cell carcinoma.
Manevich, Lev; Okita, Yukari; Okano, Yasuhito; Sugasawa, Takehito; Kawanishi, Kunio; Poullikkas, Thanasis; Dang Cao, Linda T L; Zheng, Ling; Nakayama, Masahiro; Matsumoto, Shin; Tabuchi, Keiji; Kato, Mitsuyasu.
Afiliación
  • Manevich L; Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Okita Y; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
  • Okano Y; Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Sugasawa T; Division of Cell Dynamics, Transborder Medical Research Center, University of Tsukuba, Ibaraki, Japan.
  • Kawanishi K; Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Poullikkas T; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
  • Dang Cao LTL; Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Zheng L; Laboratory of Sports Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Nakayama M; Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Matsumoto S; Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Tabuchi K; Human Biology, School of integrative and Global Majors, University of Tsukuba, Ibaraki, Japan.
  • Kato M; Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Cancer Sci ; 113(9): 3244-3254, 2022 Sep.
Article en En | MEDLINE | ID: mdl-35365934
Laryngeal squamous cell carcinoma (LSCC), although one of the most common head and neck cancers, has a static or slightly decreased survival rate because of difficulties in early diagnosis, lack of effective molecular targeting therapy, and severe dysfunction after radical surgical treatments. Therefore, a novel therapeutic target is crucial to increase treatment efficacy and survival rates in these patients. Glycoprotein NMB (GPNMB), whose role in LSCC remains elusive, is a type 1 transmembrane protein involved in malignant progression of various cancers, and its high expression is thought to be a poor prognostic factor. In this study, we showed that GPNMB expression levels in LSCC samples are significantly higher than those in normal tissues, and GPNMB expression is observed mostly in growth-arrested cancer cells. Furthermore, knockdown of GPNMB reduces monolayer cellular proliferation, cellular migration, and tumorigenic growth, while GPNMB protein displays an inverse relationship with Ki-67 levels. Therefore, we conclude that GPNMB may be an attractive target for future LSCC therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Laríngeas / MicroARNs / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Cancer Sci Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Laríngeas / MicroARNs / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Cancer Sci Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido