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Seroprevalence of antibodies against SARS-CoV-2 in the adult population during the pre-vaccination period, Norway, winter 2020/21.
Anda, Erik Eik; Braaten, Tonje; Borch, Kristin Benjaminsen; Nøst, Therese Haugdahl; Chen, Sairah L F; Lukic, Marko; Lund, Eiliv; Forland, Frode; Leon, David A; Winje, Brita Askeland; Kran, Anne-Marte Bakken; Kalager, Mette; Johansen, Fridtjof Lund; Sandanger, Torkjel M.
Afiliación
  • Anda EE; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Braaten T; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Borch KB; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Nøst TH; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Chen SLF; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Lukic M; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Lund E; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Forland F; Norwegian Institute of Public Health, Oslo, Norway.
  • Leon DA; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Winje BA; Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Kran AB; Norwegian Institute of Public Health, Oslo, Norway.
  • Kalager M; Norwegian Institute of Public Health, Oslo, Norway.
  • Johansen FL; Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway.
  • Sandanger TM; Clinical Effectiveness Research Group, Oslo University Hospital, Oslo, Norway.
Euro Surveill ; 27(13)2022 03.
Article en En | MEDLINE | ID: mdl-35362405
BackgroundSince March 2020, 440 million people worldwide have been diagnosed with COVID-19, but the true number of infections with SARS-CoV-2 is higher. SARS-CoV-2 antibody seroprevalence can add crucial epidemiological information about population infection dynamics.AimTo provide a large population-based SARS-CoV-2 seroprevalence survey from Norway; we estimated SARS-CoV-2 seroprevalence before introduction of vaccines and described its distribution across demographic groups.MethodsIn this population-based cross-sectional study, a total of 110,000 people aged 16 years or older were randomly selected during November-December 2020 and invited to complete a questionnaire and provide a dried blood spot (DBS) sample.ResultsThe response rate was 30% (31,458/104,637); compliance rate for return of DBS samples was 88% (27,700/31,458). National weighted and adjusted seroprevalence was 0.9% (95% CI (confidence interval): 0.7-1.0). Seroprevalence was highest among those aged 16-19 years (1.9%; 95% CI: 0.9-2.9), those born outside the Nordic countries 1.4% (95% CI: 1.0-1.9), and in the counties of Oslo 1.7% (95% CI: 1.2-2.2) and Vestland 1.4% (95% CI: 0.9-1.8). The ratio of SARS-CoV-2 seroprevalence (0.9%) to cumulative incidence of virologically detected cases by mid-December 2020 (0.8%) was slightly above one. SARS-CoV-2 seroprevalence was low before introduction of vaccines in Norway and was comparable to virologically detected cases, indicating that most cases in the first 10 months of the pandemic were detected.ConclusionFindings suggest that preventive measures including contact tracing have been effective, people complied with physical distancing recommendations, and local efforts to contain outbreaks have been essential.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Humans Idioma: En Revista: Euro Surveill Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Suecia
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Humans Idioma: En Revista: Euro Surveill Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Suecia