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Measures of glucose homeostasis during and after duodenal exclusion using a duodenal-jejunal bypass liner in a normoglycemic, nonobese canine model.
Paszkiewicz, Rebecca L; Burch, Miguel A; Asare Bediako, Isaac; Mkrtchyan, Hasmik; Piccinini, Francesca; Ader, Marilyn; Bresee, Catherine; Bergman, Richard N.
Afiliación
  • Paszkiewicz RL; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: rpaszkiewicz@mednet.ucla.edu.
  • Burch MA; Minimally Invasive and GI Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
  • Asare Bediako I; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Mkrtchyan H; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Piccinini F; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Ader M; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Bresee C; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Surg Obes Relat Dis ; 18(6): 694-702, 2022 06.
Article en En | MEDLINE | ID: mdl-35361540
BACKGROUND: Discovering the role duodenal exclusion plays in weight loss and resolution of type 2 diabetes (T2D) may help refine the surgical and nonsurgical treatment of obesity and T2D. OBJECTIVES: To assess changes in glucose homeostasis due to duodenal exclusion using a duodenal-jejunal bypass liner (DJBL) in a nonobese canine model. SETTING: Academic laboratory setting. METHODS: An intravenous glucose tolerance test (IVGTT), and a mixed-meal tolerance test (MMTT) at baseline, 1, and 6 weeks post DJBL implantation (I1 and I6, respectively), and 1 and 6 weeks post DJBL removal (R1 and R6, respectively) were done in canines (n = 7) fed a normal chow diet. RESULTS: Placement of the DJBL induced weight loss that was maintained until 4 weeks post removal (R4), despite normal food intake. Total bile acids (TBA) and glucagon-like peptide-1 (GLP-1) during the MMTT were significantly increased at I1 and were associated with increased lactate and free fatty acids. Hypoglycemia counter-regulation was blunted during the IVGTT at I1 and I6, returning to baseline at R1. While there were no changes to insulin sensitivity during the experiment, glucose tolerance was significantly increased following the removal of the DJBL at R1. CONCLUSION: These data show that in a normoglycemic, nonobese canine model, duodenal exclusion induces energy intake-independent weight loss and negative metabolic effects that are reversed following re-exposure of the small intestine to nutrients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Cirugía Bariátrica Límite: Animals / Humans Idioma: En Revista: Surg Obes Relat Dis Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Cirugía Bariátrica Límite: Animals / Humans Idioma: En Revista: Surg Obes Relat Dis Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos