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Plasma metabolomics reveals disrupted response and recovery following maximal exercise in myalgic encephalomyelitis/chronic fatigue syndrome.
Germain, Arnaud; Giloteaux, Ludovic; Moore, Geoffrey E; Levine, Susan M; Chia, John K; Keller, Betsy A; Stevens, Jared; Franconi, Carl J; Mao, Xiangling; Shungu, Dikoma C; Grimson, Andrew; Hanson, Maureen R.
Afiliación
  • Germain A; Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
  • Giloteaux L; Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
  • Moore GE; Department of Exercise Science and Athletic Training, Ithaca College, Ithaca, New York, USA.
  • Levine SM; Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
  • Chia JK; EVMED Research, Torrance, California, USA.
  • Keller BA; Department of Exercise Science and Athletic Training, Ithaca College, Ithaca, New York, USA.
  • Stevens J; Workwell Foundation, Ripon, California, USA.
  • Franconi CJ; Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
  • Mao X; Department of Neuroradiology, Weill Cornell Medical College, New York, New York, USA.
  • Shungu DC; Department of Neuroradiology, Weill Cornell Medical College, New York, New York, USA.
  • Grimson A; Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
  • Hanson MR; Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
JCI Insight ; 7(9)2022 05 09.
Article en En | MEDLINE | ID: mdl-35358096
Post-exertional malaise (PEM) is a hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We monitored the evolution of 1157 plasma metabolites in 60 ME/CFS (45 female, 15 male) and 45 matched healthy control participants (30 female, 15 male) before and after 2 maximal cardiopulmonary exercise test (CPET) challenges separated by 24 hours, with the intent of provoking PEM in patients. Four time points allowed exploration of the metabolic response to maximal energy-producing capacity and the recovery pattern of participants with ME/CFS compared with the healthy control group. Baseline comparison identified several significantly different metabolites, along with an enriched percentage of yet-to-be identified compounds. Additionally, temporal measures demonstrated an increased metabolic disparity between cohorts, including unknown metabolites. The effects of exertion in the ME/CFS cohort predominantly highlighted lipid-related as well as energy-related pathways and chemical structure clusters, which were disparately affected by the first and second exercise sessions. The 24-hour recovery period was distinct in the ME/CFS cohort, with over a quarter of the identified pathways statistically different from the controls. The pathways that are uniquely different 24 hours after an exercise challenge provide clues to metabolic disruptions that lead to PEM. Numerous altered pathways were observed to depend on glutamate metabolism, a crucial component of the homeostasis of many organs in the body, including the brain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Fatiga Crónica Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: JCI Insight Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Fatiga Crónica Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: JCI Insight Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos