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The Role of Angiogenesis and Arteriogenesis in Myocardial Infarction and Coronary Revascularization.
Spadaccio, Cristiano; Nenna, Antonio; Rose, David; Piccirillo, Francesco; Nusca, Annunziata; Grigioni, Francesco; Chello, Massimo; Vlahakes, Gus J.
Afiliación
  • Spadaccio C; Cardiac Surgery, Massachusetts General Hospital & Harvard Medical School, Boston, USA. cristianospadaccio@gmail.com.
  • Nenna A; Cardiac Surgery, Golden Jubilee National Hospital & University of Glasgow, Glasgow, UK. cristianospadaccio@gmail.com.
  • Rose D; Cardiac Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Piccirillo F; Cardiac Surgery, Lancashire Cardiac Centre, Blackpool Victoria Hospital, Blackpool, UK.
  • Nusca A; Cardiology, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Grigioni F; Cardiology, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Chello M; Cardiology, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Vlahakes GJ; Cardiac Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
J Cardiovasc Transl Res ; 15(5): 1024-1048, 2022 10.
Article en En | MEDLINE | ID: mdl-35357670
Surgical myocardial revascularization is associated with long-term survival benefit in patients with multivessel coronary artery disease. However, the exact biological mechanisms underlying the clinical benefits of myocardial revascularization have not been elucidated yet. Angiogenesis and arteriogenesis biologically leading to vascular collateralization are considered one of the endogenous mechanisms to preserve myocardial viability during ischemia, and the presence of coronary collateralization has been regarded as one of the predictors of long-term survival in patients with coronary artery disease (CAD). Some experimental studies and indirect clinical evidence on chronic CAD confirmed an angiogenetic response induced by myocardial revascularization and suggested that revascularization procedures could constitute an angiogenetic trigger per se. In this review, the clinical and basic science evidence regarding arteriogenesis and angiogenesis in both CAD and coronary revascularization is analyzed with the aim to better elucidate their significance in the clinical arena and potential therapeutic use.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Intervención Coronaria Percutánea / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Intervención Coronaria Percutánea / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos