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Human liver organoid derived intra-hepatic bile duct cells support SARS-CoV-2 infection and replication.
Lui, Vincent Chi-Hang; Hui, Kenrie Pui-Yan; Babu, Rosanna Ottakandathil; Yue, Haibing; Chung, Patrick Ho-Yu; Tam, Paul Kwong-Hang; Chan, Michael Chi-Wai; Wong, Kenneth Kak-Yuen.
Afiliación
  • Lui VC; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pofulam Road, Pok Fu Lam, Hong Kong.
  • Hui KP; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Pok Fu Lam, Hong Kong.
  • Babu RO; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pofulam Road, Pok Fu Lam, Hong Kong.
  • Yue H; MRC WIMM Centre For Computational Biology, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • Chung PH; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pofulam Road, Pok Fu Lam, Hong Kong.
  • Tam PK; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pofulam Road, Pok Fu Lam, Hong Kong.
  • Chan MC; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pofulam Road, Pok Fu Lam, Hong Kong.
  • Wong KK; Dr. Li Dak-Sum Research Centre, The University of Hong Kong - Karolinska Institutet Collaboration in Regenerative Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Sci Rep ; 12(1): 5375, 2022 03 30.
Article en En | MEDLINE | ID: mdl-35354880
Although the main route of infection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the respiratory tract, liver injury is also commonly seen in many patients, as evidenced by deranged parenchymal liver enzymes. Furthermore, the severity of liver damage has been shown to correlate with higher mortality. Overall, the mechanism behind the liver injury remains unclear. We showed in this study that intra-hepatic bile duct cells could be grown using a human liver organoid platform. The cholangiocytes were not only susceptible to SARS-CoV-2 infection, they also supported efficient viral replication. We also showed that SARS-CoV-2 replication was much higher than SARS-CoV. Our findings suggested direct cytopathic viral damage being a mechanism for SARS-CoV-2 liver injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conductos Biliares Extrahepáticos / COVID-19 Límite: Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Hong Kong Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conductos Biliares Extrahepáticos / COVID-19 Límite: Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Hong Kong Pais de publicación: Reino Unido